[HTML][HTML] Limitations of oxygen delivery to cells in culture: An underappreciated problem in basic and translational research
Molecular oxygen is one of the most important variables in modern cell culture systems.
Fluctuations in its concentration can affect cell growth, differentiation, signaling, and free …
Fluctuations in its concentration can affect cell growth, differentiation, signaling, and free …
Defining physiological normoxia for improved translation of cell physiology to animal models and humans
TP Keeley, GE Mann - Physiological reviews, 2019 - journals.physiology.org
The extensive oxygen gradient between the air we breathe (Po2~ 21 kPa) and its ultimate
distribution within mitochondria (as low as~ 0.5–1 kPa) is testament to the efforts expended …
distribution within mitochondria (as low as~ 0.5–1 kPa) is testament to the efforts expended …
BNIP3L/NIX-mediated mitophagy: molecular mechanisms and implications for human disease
Y Li, W Zheng, Y Lu, Y Zheng, L Pan, X Wu… - Cell Death & …, 2021 - nature.com
Mitophagy is a highly conserved cellular process that maintains the mitochondrial quantity
by eliminating dysfunctional or superfluous mitochondria through autophagy machinery. The …
by eliminating dysfunctional or superfluous mitochondria through autophagy machinery. The …
Microsensor systems for cell metabolism–from 2D culture to organ-on-chip
Microsensor systems for cell metabolism are essential tools for investigation and
standardization in cell culture. Electrochemical and optical read-out schemes dominate …
standardization in cell culture. Electrochemical and optical read-out schemes dominate …
Human-on-a-chip design strategies and principles for physiologically based pharmacokinetics/pharmacodynamics modeling
HE Abaci, ML Shuler - Integrative Biology, 2015 - academic.oup.com
Advances in maintaining multiple human tissues on microfluidic platforms has led to a
growing interest in the development of microphysiological systems for drug development …
growing interest in the development of microphysiological systems for drug development …
Automated method for the rapid and precise estimation of adherent cell culture characteristics from phase contrast microscopy images
N Jaccard, LD Griffin, A Keser… - Biotechnology and …, 2014 - Wiley Online Library
The quantitative determination of key adherent cell culture characteristics such as
confluency, morphology, and cell density is necessary for the evaluation of experimental …
confluency, morphology, and cell density is necessary for the evaluation of experimental …
Hyaluronic acid facilitates chondrogenesis and matrix deposition of human adipose derived mesenchymal stem cells and human chondrocytes co-cultures
E Amann, P Wolff, E Breel, M Van Griensven… - Acta Biomaterialia, 2017 - Elsevier
Clinical success on cartilage regeneration could be achieved by using available
biomaterials and cell-based approaches. In this study, we have developed a composite gel …
biomaterials and cell-based approaches. In this study, we have developed a composite gel …
Functional importance of Dicer protein in the adaptive cellular response to hypoxia
JJD Ho, JL Metcalf, MS Yan, PJ Turgeon… - Journal of Biological …, 2012 - ASBMB
The processes by which cells sense and respond to ambient oxygen concentration are
fundamental to cell survival and function, and they commonly target gene regulatory events …
fundamental to cell survival and function, and they commonly target gene regulatory events …
Every breath you take: non-invasive real-time oxygen biosensing in two-and three-dimensional microfluidic cell models
Knowledge on the availability of dissolved oxygen inside microfluidic cell culture systems is
vital for recreating physiological-relevant microenvironments and for providing reliable and …
vital for recreating physiological-relevant microenvironments and for providing reliable and …