The role of X-inactivation is often ignored as a prime cause of sex differences in disease.
Yet, the way males and females express their X-linked genes has a major role in the …

Adrenoleukodystrophy (ALD) is a rare X‐linked disease caused by a mutation of the
peroxisomal ABCD1 gene. This review summarizes our current understanding of the …

The human androgen-receptor gene (HUMARA; GenBank) contains a highly polymorphic
trinucleotide repeat in the first exon. We have found that the methylation of HpaII and HhaI …

Abstract ADRENOLEUKODYSTROPHY (ALD) is an X-linked disease affecting 1/20,000
males either as cerebral ALD in childhood or as adrenomyeloneuropathy (AMN) in adults1 …

Background X chromosome inactivation is the epigenetic silencing of the majority of the
genes on one of the X chromosomes in XX therian mammals. In humans, approximately …

▪ Abstract The inactive X chromosome differs from the active X in a number of ways; some of
these, such as allocyclic replication and altered histone acetylation, are associated with all …

Abstract X-linked adrenoleukodystrophy (X-ALD) is caused by a defect in the gene ABCD1,
which maps to Xq28 and codes for a peroxisomal membrane protein that is a member of the …

Abstract" HALDANE's rule" states that, if species hybrids of one sex only are inviable or
sterile, the afflicted sex is much more likely to be heterogametic (XY) than homogametic …

X-linked adrenoleukodystrophy is the most common peroxisomal disorder. The disease is
caused by mutations in the ABCD1 gene that encodes the peroxisomal transporter of very …

Inactivation of one X chromosome in mammalian females achieves dosage compensation
between XX females and XY males; however, over 15% of human X-linked genes continue …