Vascular dysfunction in preeclampsia

MA Opichka, MW Rappelt, DD Gutterman, JL Grobe… - Cells, 2021 - mdpi.com
Preeclampsia is a life-threatening pregnancy-associated cardiovascular disorder
characterized by hypertension and proteinuria at 20 weeks of gestation. Though its exact …

Pathogenesis of preeclampsia

BC Young, RJ Levine… - Annual Review of …, 2010 - annualreviews.org
Preeclampsia is a systemic syndrome that occurs in 3 to 5% of pregnant women and
classically manifests as new-onset hypertension and proteinuria after 20 weeks of gestation …

Soluble endoglin contributes to the pathogenesis of preeclampsia

S Venkatesha, M Toporsian, C Lam, J Hanai… - Nature medicine, 2006 - nature.com
Preeclampsia is a pregnancy-specific hypertensive syndrome that causes substantial
maternal and fetal morbidity and mortality. Maternal endothelial dysfunction mediated by …

Hypoxia-inducible factor-1 mediates the biological effects of oxygen on human trophoblast differentiation through TGFβ3

I Caniggia, H Mostachfi, J Winter… - The Journal of …, 2000 - Am Soc Clin Investig
During early pregnancy, placentation occurs in a relatively hypoxic environment that is
essential for appropriate embryonic development. Intervillous blood flow increases around …

Cytokines, chemokines and growth factors in endometrium related to implantation

E Dimitriadis, CA White, RL Jones… - Human reproduction …, 2005 - academic.oup.com
The complexity of the events of embryo implantation and placentation is exemplified by the
number and range of cytokines with demonstrated roles in these processes. Disturbance of …

Endoglin is an accessory protein that interacts with the signaling receptor complex of multiple members of the transforming growth factor-β superfamily

NP Barbara, JL Wrana, M Letarte - Journal of Biological Chemistry, 1999 - ASBMB
Endoglin (CD105) is a transmembrane glycoprotein that binds transforming growth factor
(TGF)-β1 and-β3, and coprecipitates with the Ser/Thr kinase signaling receptor complex by …

TGF-β superfamily expression and actions in the endometrium and placenta

RL Jones, C Stoikos, JK Findlay… - Reproduction, 2006 - rep.bioscientifica.com
Transforming growth factor β (TGFβ) superfamily members are closely associated with tissue
remodelling events and reproductive processes. This review summarises the current state of …

Oxygen and placental development during the first trimester: implications for the pathophysiology of pre-eclampsia

I Caniggia, J Winter, SJ Lye, M Post - Placenta, 2000 - Elsevier
During early pregnancy, placentation occurs in a relatively hypoxic environment which is
essential for appropriate embryonic development. Intervillous blood flow increases at …

A historical overview of preeclampsia‐eclampsia

MJ Bell - Journal of Obstetric, Gynecologic & Neonatal Nursing, 2010 - Elsevier
Preeclampsia is a hypertensive, multisystem disorder of pregnancy whose etiology remains
unknown. Although management is evidence‐based, preventative measures/screening …

Kisspeptin-10, a KiSS-1/metastin-derived decapeptide, is a physiological invasion inhibitor of primary human trophoblasts

M Bilban, N Ghaffari-Tabrizi… - Journal of cell …, 2004 - journals.biologists.com
Trophoblast invasion of the uterine extracellular matrix, a critical process of human
implantation and essential for fetal development, is a striking example of controlled …