Planarians are members of the Platyhelminthes (flatworms). These animals have evolved a
remarkable stem cell system. A single pluripotent adult stem cell type (“neoblast”) gives rise …

Planarians are a group of flatworms. Some planarian species have remarkable regenerative
abilities, which involve abundant pluripotent adult stem cells. This makes these worms a …

Bioactive peptides (ie, neuropeptides or peptide hormones) represent the largest class of
cell-cell signaling molecules in metazoans and are potent regulators of neural and …

Background The ability to assess gene function is essential for understanding biological
processes. Currently, RNA interference (RNAi) is the only technique available to assess …

Schistosomiasis is among the most prevalent human parasitic diseases, affecting more than
200 million people worldwide. The aetiological agents of this disease are trematode …

The germline of multicellular animals is segregated from somatic tissues, which is an
essential developmental process for the next generation. Although certain ecdysozoans and …

Having an almost unlimited capacity to regenerate tissues lost to age and injury, planarians
have long fascinated naturalists. In the Western hemisphere alone, their documented history …

Pluripotency is a central, well-studied feature of embryonic development, but the role of
pluripotent cell regulation in somatic tissue regeneration remains poorly understood. In …

Planarian flatworms are an exception among bilaterians in that they possess a large pool of
adult stem cells that enables them to promptly regenerate any part of their body, including …

Freshwater planaria possess extreme regeneration capabilities mediated by abundant,
pluripotent stem cells (neoblasts) in adult animals. Although planaria emerged as an …