Alpha-lipoic acid: An antioxidant with anti-aging properties for disease therapy

M Shanaida, R Lysiuk, O Mykhailenko… - Current Medicinal …, 2025 - benthamdirect.com
The anti-aging effects of alpha-lipoic acid (αLA), a natural antioxidant synthesized in human
tissues, have attracted a growing interest in recent years. αLA is a short-chain sulfur …

A transdermal drug delivery system based on nucleic acid nanomaterials for skin photodamage treatment

Y Xie, J He, S Li, X Chen, T Zhang… - Advanced Functional …, 2023 - Wiley Online Library
Skin photodamage, which is induced by ultraviolet (UV) radiation, is a prevalent cause of
skin damage. In this study, a transdermal drug delivery system is developed for the topical …

Effects of oral alpha-lipoic acid treatment on diabetic polyneuropathy: a meta-analysis and systematic review

RY Hsieh, IC Huang, C Chen, JY Sung - Nutrients, 2023 - mdpi.com
Alpha-lipoic acid (ALA) was found to improve the symptoms in patients with diabetic
sensorimotor peripheral neuropathy (DSPN) by reducing oxidative stress and ameliorating …

Molecular immunological mechanisms of impaired wound healing in diabetic foot ulcers (DFU), current therapeutic strategies and future directions

F Mohsin, S Javaid, M Tariq, M Mustafa - International …, 2024 - Elsevier
Diabetic foot ulcer (DFU) is a foremost cause of amputation in diabetic patients.
Consequences of DFU include infections, decline in limb function, hospitalization …

Biological applications of lipoic acid-based polymers: an old material with new promise

Q Yu, Z Fang, S Luan, L Wang, H Shi - Journal of Materials Chemistry …, 2024 - pubs.rsc.org
Lipoic acid (LA) is a versatile antioxidant to be used in various oxidation-reducing diseases
over the past 70 years. Attributing to the large five-membered ring tension, the dynamic …

[HTML][HTML] The Multifaceted Role of Alpha-Lipoic Acid in Cancer Prevention, Occurrence, and Treatment

S Yan, J Lu, B Chen, L Yuan, L Chen, L Ju, W Cai… - Antioxidants, 2024 - mdpi.com
Alpha-lipoic acid (ALA) is a naturally occurring compound synthesized by mitochondria and
widely distributed in both animal and plant tissues. It primarily influences cellular metabolism …

Anti-inflammatory-antioxidant modifications and synbiotics improved health-related conditions in patients with progressive forms of multiple sclerosis: A single-center …

AR Moravejolahkami, A Chitsaz… - … Therapies in Clinical …, 2023 - Elsevier
Background and purpose There is growing evidence that dietary modification can improve
clinical manifestations in multiple sclerosis (MS) patients. This study aimed to assess the …

The neuroprotective effects of alpha lipoic acid in rotenone-induced Parkinson's disease in mice via activating PI3K/AKT pathway and antagonizing related …

MI Fahmy, SS Khalaf, RA Elrayess - European Journal of Pharmacology, 2024 - Elsevier
Parkinson's disease (PD) is an idiopathic disease caused by the loss or degeneration of the
dopaminergic (dopamine-producing) neurons in the brain and characterized by various …

Novel drug targets and emerging pharmacotherapies in neuropathic pain

J Bernatoniene, A Sciupokas, DM Kopustinskiene… - Pharmaceutics, 2023 - mdpi.com
Neuropathic pain is a debilitating condition characterized by abnormal signaling within the
nervous system, resulting in persistent and often intense sensations of pain. It can arise from …

[HTML][HTML] Assessing Gender Differences in Neuropathic Pain Management: Findings from a Real-Life Clinical Cross-Sectional Observational Study

G Marcianò, A Siniscalchi, G Di Gennaro… - Journal of Clinical …, 2024 - mdpi.com
Introduction: Neuropathic pain is defined as pain induced by a lesion or disease of the
somatosensory nervous system. Pharmacological and non-pharmacological treatments are …