Resolvins in inflammation: emergence of the pro-resolving superfamily of mediators

CN Serhan, BD Levy - The Journal of clinical investigation, 2018 - Am Soc Clin Investig
Countless times each day, the acute inflammatory response protects us from invading
microbes, injuries, and insults from within, as in surgery-induced tissue injury. These …

Anti-inflammatory effects of omega-3 fatty acids in the brain: physiological mechanisms and relevance to pharmacology

S Laye, A Nadjar, C Joffre, RP Bazinet… - Pharmacological …, 2018 - Elsevier
Classically, polyunsaturated fatty acids (PUFA) were largely thought to be relatively inert
structural components of brain, largely important for the formation of cellular membranes …

Docosahexaenoic acid and cognition throughout the lifespan

MJ Weiser, CM Butt, MH Mohajeri - Nutrients, 2016 - mdpi.com
Docosahexaenoic acid (DHA) is the predominant omega-3 (n-3) polyunsaturated fatty acid
(PUFA) found in the brain and can affect neurological function by modulating signal …

Docosahexaenoic acid (DHA), a fundamental fatty acid for the brain: New dietary sources

F Echeverría, R Valenzuela… - … and Essential Fatty …, 2017 - Elsevier
Abstract Docosahexaenoic acid (C22: 6n-3, DHA) is a long-chain polyunsaturated fatty acid
of marine origin fundamental for the formation and function of the nervous system …

Perinatal dietary polyunsaturated fatty acids in brain development, role in neurodevelopmental disorders

M Martinat, M Rossitto, M Di Miceli, S Layé - Nutrients, 2021 - mdpi.com
n-3 and n-6 polyunsaturated fatty acids (PUFAs) are essential fatty acids that are provided
by dietary intake. Growing evidence suggests that n-3 and n-6 PUFAs are paramount for …

[HTML][HTML] Brain docosahexaenoic acid uptake and metabolism

RJS Lacombe, R Chouinard-Watkins… - Molecular Aspects of …, 2018 - Elsevier
Docosahexaenoic acid (DHA) is the most abundant n-3 polyunsaturated fatty acid in the
brain where it serves to regulate several important processes and, in addition, serves as a …

Dietary docosahexaenoic acid (DHA) as lysophosphatidylcholine, but not as free acid, enriches brain DHA and improves memory in adult mice

D Sugasini, R Thomas, PCR Yalagala, LM Tai… - Scientific Reports, 2017 - nature.com
Docosahexaenoic acid (DHA) is uniquely concentrated in the brain, and is essential for its
function, but must be mostly acquired from diet. Most of the current supplements of DHA …

[HTML][HTML] Unraveling the impact of Omega-3 polyunsaturated fatty acids on blood-brain barrier (BBB) integrity and glymphatic function

J Wen, SK Satyanarayanan, A Li, L Yan, Z Zhao… - Brain, Behavior, and …, 2024 - Elsevier
Alzheimer's disease (AD) and other forms of dementia represent major public health
challenges but effective therapeutic options are limited. Pathological brain aging is …

Docosahexaenoic acid preserves visual function by maintaining correct disc morphology in retinal photoreceptor cells

H Shindou, H Koso, J Sasaki, H Nakanishi… - Journal of Biological …, 2017 - ASBMB
Docosahexaenoic acid (DHA) has essential roles in photoreceptor cells in the retina and is
therefore crucial to healthy vision. Although the influence of dietary DHA on visual acuity is …

Wnt signaling activates MFSD2A to suppress vascular endothelial transcytosis and maintain blood-retinal barrier

Z Wang, CH Liu, S Huang, Z Fu, Y Tomita… - Science …, 2020 - science.org
Breakdown of the blood-retinal barrier (BRB) causes retinal edema and vision loss. We
investigated the role of Wnt signaling in maintaining the BRB by limiting transcytosis. Mice …