The field of mitochondrial ion channels underwent a rapid development during the last
decade, thanks to the molecular identification of some of the nuclear-encoded organelle …

The large-conductance calcium-and voltage-activated K+ channel (BKCa) are encoded by
the Kcnma1 gene. They are ubiquitously expressed in neuronal, smooth muscle, astrocytes …

Mitochondria are subcellular organelles evolved by endosymbiosis of bacteria with
eukaryotic cells characteristics. They are the main source of ATP in the cell and play a …

In the 1970s, calcium-activated potassium currents were recorded for the first time. In
10years, this Ca2+-activated potassium channel was identified in rat skeletal muscle …

Mitochondria have been recognized as key organelles in cardiac physiology and are
potential targets for clinical interventions to improve cardiac function. Mitochondrial …

Population aging, as well as the handling of age-associated diseases, is a worldwide
increasing concern. Among them, Alzheimer's disease stands out as the major cause of …

Redox reactions exert a profound influence on numerous cellular functions with
mitochondria playing a central role in orchestrating these processes. This pivotal …

Extracellular vesicles (EVs) are associated with intercellular communications, immune
responses, viral pathogenicity, cardiovascular diseases, neurological disorders, and cancer …

Chloride is a key anion involved in cellular physiology by regulating its homeostasis and
rheostatic processes. Changes in cellular Cl− concentration result in differential regulation of …

Despite significant advances in our understanding of the mechanisms that underlie age-
related physiological decline, our ability to translate these insights into actionable strategies …