DNA repair in cancer: emerging targets for personalized therapy
R Abbotts, N Thompson… - Cancer management and …, 2014 - Taylor & Francis
Genomic deoxyribonucleic acid (DNA) is under constant threat from endogenous and
exogenous DNA damaging agents. Mammalian cells have evolved highly conserved DNA …
exogenous DNA damaging agents. Mammalian cells have evolved highly conserved DNA …
Molecular basis of aflatoxin-induced mutagenesis—role of the aflatoxin B1-formamidopyrimidine adduct
YC Lin, L Li, AV Makarova, PM Burgers… - …, 2014 - academic.oup.com
Abstract Aflatoxin B1 (AFB1) is a known carcinogen associated with early-onset
hepatocellular carcinoma (HCC) and is thought to contribute to over half a million new HCCs …
hepatocellular carcinoma (HCC) and is thought to contribute to over half a million new HCCs …
A comprehensive strategy to discover inhibitors of the translesion synthesis DNA polymerase κ
K Yamanaka, D Dorjsuren, RL Eoff, M Egli, DJ Maloney… - 2012 - journals.plos.org
Human DNA polymerase kappa (pol κ) is a translesion synthesis (TLS) polymerase that
catalyzes TLS past various minor groove lesions including N 2-dG linked acrolein-and …
catalyzes TLS past various minor groove lesions including N 2-dG linked acrolein-and …
N-Aroyl Indole Thiobarbituric Acids as Inhibitors of DNA Repair and Replication Stress Response Polymerases
GE Coggins, L Maddukuri, NR Penthala… - ACS chemical …, 2013 - ACS Publications
Using a robust and quantitative assay, we have identified a novel class of DNA polymerase
inhibitors that exhibits some specificity against an enzyme involved in resistance to anti …
inhibitors that exhibits some specificity against an enzyme involved in resistance to anti …
Leukotriene biosynthesis inhibitor MK886 impedes DNA polymerase activity
Specialized DNA polymerases participate in replication stress responses and in DNA repair
pathways that function as barriers against cellular senescence and genomic instability …
pathways that function as barriers against cellular senescence and genomic instability …