The molecular mechanisms and therapeutic strategies of EMT in tumor progression and metastasis

Y Huang, W Hong, X Wei - Journal of hematology & oncology, 2022 - Springer
Epithelial–mesenchymal transition (EMT) is an essential process in normal embryonic
development and tissue regeneration. However, aberrant reactivation of EMT is associated …

Circulating tumor cell isolation for cancer diagnosis and prognosis

Z Deng, S Wu, Y Wang, D Shi - EBioMedicine, 2022 - thelancet.com
Circulating tumor cells (CTCs) are tumor cells that shed from the primary tumor and
intravasate into the peripheral blood circulation system responsible for metastasis. Sensitive …

Channel innovations for inertial microfluidics

W Tang, S Zhu, D Jiang, L Zhu, J Yang, N Xiang - Lab on a Chip, 2020 - pubs.rsc.org
Inertial microfluidics has gained significant attention since first being proposed in 2007
owing to the advantages of simplicity, high throughput, precise manipulation, and freedom …

Inertial microfluidics: current status, challenges, and future opportunities

N Xiang, Z Ni - Lab on a Chip, 2022 - pubs.rsc.org
Inertial microfluidics uses the hydrodynamic effects induced at finite Reynolds numbers to
achieve passive manipulation of particles, cells, or fluids and offers the advantages of high …

Updates on liquid biopsy: Current trends and future perspectives for clinical application in solid tumors

P Pinzani, V D'Argenio, M Del Re… - Clinical Chemistry and …, 2021 - degruyter.com
Despite advances in screening and therapeutics cancer continues to be one of the major
causes of morbidity and mortality worldwide. The molecular profile of tumor is routinely …

Orchestration of collective migration and metastasis by tumor cell clusters

A Yamamoto, AE Doak… - Annual Review of …, 2023 - annualreviews.org
Metastatic dissemination has lethal consequences for cancer patients. Accruing evidence
supports the hypothesis that tumor cells can migrate and metastasize as clusters of cells …

EMT-associated heterogeneity in circulating tumor cells: sticky friends on the road to metastasis

A Genna, AM Vanwynsberghe, AV Villard, C Pottier… - Cancers, 2020 - mdpi.com
Epithelial–mesenchymal transitions (EMTs) generate hybrid phenotypes with an enhanced
ability to adapt to diverse microenvironments encountered during the metastatic spread …

Nanoparticle amplification labeling for high-performance magnetic cell sorting

Z Wang, H Wang, S Lin, S Ahmed, S Angers… - Nano …, 2022 - ACS Publications
Magnetic cell sorting is an enabling tool for the isolation of specific cellular subpopulations
for downstream applications and requires the cells to be labeled by a sufficient number of …

The role of circulating tumor cells in the metastatic cascade: biology, technical challenges, and clinical relevance

H Dianat-Moghadam, M Azizi, Z Eslami-S… - Cancers, 2020 - mdpi.com
Metastases and cancer recurrence are the main causes of cancer death. Circulating Tumor
Cells (CTCs) and disseminated tumor cells are the drivers of cancer cell dissemination. The …

Microfluidic techniques for isolation, formation, and characterization of circulating tumor cells and clusters

C Macaraniag, Q Luan, J Zhou, I Papautsky - APL bioengineering, 2022 - pubs.aip.org
Circulating tumor cell (CTC) clusters that are shed from the primary tumor into the
bloodstream are associated with a poor prognosis, elevated metastatic potential, higher …