Acute myeloid leukemia (AML) is the most common form of acute leukemia in adults and the
second most common form of acute leukemia in children. Despite this, very little …

Acute myeloid leukemia (AML) is a hematological malignancy characterized by uncontrolled
proliferation, differentiation arrest, and accumulation of immature myeloid progenitors …

Valproic acid (VPA), a branched short‐chain fatty acid, is widely used as an antiepileptic
drug and a mood stabilizer. Antiepileptic properties have been attributed to inhibition of …

Cancer drug resistance is an enormous problem. It is responsible for most relapses in
cancer patients following apparent remission after successful therapy. Understanding …

Retinoids (ie, vitamin A, all-trans retinoic acid, and related signaling molecules) induce the
differentiation of various types of stem cells. Nuclear retinoic acid receptors mediate most but …

Reversible acetylation mediated by histone deacetylases (HDACs) influences a broad
repertoire of physiological processes, many of which are aberrantly controlled in tumor cells …

Abnormal epigenetic control is a common early event in tumour progression, and aberrant
acetylation in particular has been implicated in tumourigenesis. One of the most promising …

The human HDAC (histone deacetylase) family, a well-validated anticancer target, plays a
key role in the control of gene expression through regulation of transcription. While HDACs …

Thyroid hormones exert their effects through alpha (TRα1) and beta (TRβ1 and TRβ2)
receptors. Here we describe a child with classic features of hypothyroidism (growth …

Advances in our understanding of the intricate molecular mechanisms for transformation of a
normal cell to a cancer cell, and the aberrant control of complementary pathways, have …