The lipid composition of cellular organelles is tailored to suit their specialized tasks. A
fundamental transition in the lipid landscape divides the secretory pathway in early and late …

Here, we provide an update of our review on homeobox genes that we wrote together with
Walter Gehring in 1994. Since then, comprehensive surveys of homeobox genes have …

The endoplasmic reticulum (ER) has a broad localization throughout the cell and forms
direct physical contacts with all other classes of membranous organelles, including the …

St AR‐related lipid transfer domain‐3 (STARD 3) is a sterol‐binding protein that creates
endoplasmic reticulum (ER)–endosome contact sites. How this protein, at the crossroad …

Precise regulation of lipid biosynthesis, transport, and storage is key to the homeostasis of
cells and organisms. Cells rely on a sophisticated but poorly understood network of …

Membrane biology seeks to understand how lipids and proteins within bilayers assemble
into large structures such as organelles and the plasma membranes. Historically, lipids were …

Abnormal distribution of cellular cholesterol is associated with numerous diseases, including
cardiovascular and neurodegenerative diseases. Regulated transport of cholesterol is …

Steroidogenesis begins with cellular internalization of low-density lipoprotein particles and
subsequent intracellular processing of cholesterol. Disorders in these steps include …

Lipids are unevenly distributed within eukaryotic cells, thus defining organelle identity. How
non-vesicular transport mechanisms generate these lipid gradients between membranes …

Tether proteins attach the endoplasmic reticulum (ER) to other cellular membranes, thereby
creating contact sites that are proposed to form platforms for regulating lipid homeostasis …