Objectives Efforts towards achieving durable resin–dentin bonds have been made for
decades, including the understanding of the mechanisms underlying hybrid layer (HL) …

Objective Success in adhesive dentistry means long lasting restorations. However, there is
substantial evidence that this ideal objective is not always achieved. Current research in this …

Dentin can be described as a biological composite with collagen matrix embedded with
nanosized hydroxyapatite mineral crystallites. Matrix metalloproteinases (MMPs) and …

The limited durability of resin-dentin bonds severely compromises the lifetime of tooth-
colored restorations. Bond degradation occurs via hydrolysis of suboptimally polymerized …

OBJECTIVES: Contemporary adhesives lose their bond strength to dentin regardless of the
bonding system used. This loss relates to the hydrolysis of collagen matrix of the hybrid …

The extracellular matrix (ECM) is a complex network of macromolecules surrounding cells
providing structural support and stability to tissues. The understanding of the ECM and the …

In dentin bonding, contemporary dental adhesive systems rely on formation of the hybrid
layer, a biocomposite containing dentin collagen and polymerized resin adhesive. They are …

Objectives The biomodification of dentin is a biomimetic approach, mediated by bioactive
agents, to enhance and reinforce the dentin by locally altering the biochemistry and …

Objective To survey the recent literature from the late 1980s to recent years in order to
assess the relationship between resin degradation, catalyzed by biological factors, and …

Several studies have shown that the dentin‐resin interface is unstable due to poor infiltration
of resin monomers into the demineralized dentin matrix. This phenomenon is related to the …