Inflammasomes are multimolecular complexes with potent inflammatory activity. As such,
their activity is tightly regulated at the transcriptional and post-transcriptional levels. In this …

Abstract The Anaphase Promoting Complex (APC), a multi-subunit ubiquitin ligase,
facilitates mitotic and G1 progression, and is now recognized to play a role in maintaining …

Background: Glucocorticoids are among the most commonly prescribed drugs, but there is
no biomarker that can quantify their action. The aim of the study was to identify and validate …

Background: CD4+ T cells play an important role in body development and homeostasis.
Quantitative and functional changes in CD4+ T cells result in abnormal immune responses …

Alzheimer's disease (AD) is a neurodegenerative disorder causing 70% of dementia cases.
However, the mechanism of disease development is still elusive. Despite the availability of a …

Background Exosomes have been identified to mediate the transmission of RNAs among
different cells in tumor microenvironment, thus affecting the progression of different …

Purpose: Age-related cataract (ARC) is a major cause of vision impairment worldwide. The
E3 ubiquitin ligase RING finger protein 157 (RNF157) is involved in regulating cell survival …

The Kelch-like (KLHL) family members consist of three domains: bric-a-brac, tramtrack,
broad complex/poxvirus and zinc finger domain, BACK domain and Kelch domain, which …

Laryngeal carcinoma (LCC) is a common malignant tumor with low radiosensitivity and
generally poor response rates. The ubiquitin protein ligase E3 component n‑recognin 5 …

Toxoplasma gondii is a foodborne pathogen that can cause severe and life-threatening
infections in fetuses and immunocompromised patients. Felids are its only definitive hosts …