Hyperpolarization-activated, cyclic nucleotide-sensitive (HCN) channels are key regulators
of subthreshold membrane potentials in excitable cells. The four mammalian HCN channel …

The Src-family protein tyrosine kinases (SFKs), a subfamily of non-receptor tyrosine kinases,
are ubiquitously expressed in various cell types. Numerous studies have suggested that …

The apical dendrites of many neurons contain proximal and distal compartments that receive
synaptic inputs from different brain regions. These compartments also contain distinct …

To analyse the mechanism of Nardostachyos Radix et Rhizoma–Salidroside in the treatment
of Premature Ventricular Brats by using network pharmacology and molecular docking and …

Background and Purpose Previous studies have shown that Src can regulate inflammation
and tumour progression. However, the mechanisms by which Src regulates the inflammatory …

Cardiac sodium channel NaV1. 5 is the predominant form of sodium channels in
cardiomyocytes, which exists as a macromolecular complex and interacts with multiple …

Increasing evidence has demonstrated the potential risks of cardiac arrhythmias (such as
prolonged QT interval) using tyrosine kinase inhibitors for cancer therapy. We report here …

Background Missense mutations in the hyperpolarization‐activated cyclic nucleotide‐
modulated (HCN) channel 4 (HCN4) are one of the genetic causes of cardiac sinus …

目的: 基于网络药理学和分子对接的方法探讨桃仁红花煎治疗心律失常的有效成分,
作用靶点及其作用机制. 方法: 通过TCMSP, TCM-ID 筛选桃仁红花煎的有效成分并预测其作用 …

The Kv3. 1 channel plays a crucial role in regulating the high-frequency firing properties of
neurons. Here, we determined whether Src regulates the subcellular distributions of the Kv3 …