Stimuli-responsive ferroptosis for cancer therapy

N Kang, S Son, S Min, H Hong, C Kim, J An… - Chemical Society …, 2023 - pubs.rsc.org
Ferroptosis, an iron-dependent programmed cell death mechanism, is regulated by distinct
molecular pathways of lipid peroxidation caused by intracellular iron supplementation and …

Bioactive inorganic nanomaterials for cancer theranostics

Z Pei, H Lei, L Cheng - Chemical Society Reviews, 2023 - pubs.rsc.org
Bioactive materials are a special class of biomaterials that can react in vivo to induce a
biological response or regulate biological functions, thus achieving a better curative effect …

Tumor-generated reactive oxygen species storm for high-performance ferroptosis therapy

L Huang, J Zhu, W Xiong, J Feng, J Yang, X Lu, Y Lu… - ACS …, 2023 - ACS Publications
Ferroptosis therapy (FT) efficacy of tumors suffers from a relatively low concentration of
Fenton agents, limited hydrogen peroxide (H2O2) content, and insufficient acidity in the …

Molecular engineering of pH-responsive NIR oxazine assemblies for evoking tumor ferroptosis via triggering lysosomal dysfunction

W Li, S Yin, Y Shen, H Li, L Yuan… - Journal of the American …, 2023 - ACS Publications
Ferroptosis, a newly discovered form of regulated cell death, is emerging as a promising
approach to tumor therapy. However, the spatiotemporal control of cell-intrinsic Fenton …

Ferroptosis detection: from approaches to applications

F Zeng, S Nijiati, L Tang, J Ye, Z Zhou… - Angewandte …, 2023 - Wiley Online Library
Understanding the intricate molecular machinery that governs ferroptosis and leveraging
this accumulating knowledge could facilitate disease prevention, diagnosis, treatment, and …

Nanoprobe-based molecular imaging for tumor stratification

X Ma, M Mao, J He, C Liang, HY Xie - Chemical Society Reviews, 2023 - pubs.rsc.org
The responses of patients to tumor therapies vary due to tumor heterogeneity. Tumor
stratification has been attracting increasing attention for accurately distinguishing between …

GSH/APE1 cascade-activated nanoplatform for imaging therapy resistance dynamics and enzyme-mediated adaptive ferroptosis

R Yue, M Zhou, X Li, L Xu, C Lu, Z Dong, L Lei, H Liu… - ACS …, 2023 - ACS Publications
Ferroptosis, as a type of programmed cell death process, enables effective damage to
various cancer cells. However, we discovered that persistent oxidative stress during …

Stimuli-responsive switchable MRI nanoprobe for tumor theranostics

B Chen, L Liu, R Yue, Z Dong, C Lu, C Zhang, G Guan… - Nano Today, 2023 - Elsevier
With the advancement in magnetic resonance imaging (MRI) technology, traditional single T
1 or T 2 contrast agents struggle to meet the demend for accuracy imaging. In comparison …

A STING pathway-activatable contrast agent for MRI-guided tumor immunoferroptosis synergistic therapy

S Guo, W Xiong, J Zhu, J Feng, R Zhou, Q Fan… - Biomaterials, 2023 - Elsevier
The immunotherapy efficiency of stimulator of interferon genes (STING)-activatable drugs
(eg, 7-ethyl-10-hydroxycamptothecin, SN38) is limited by their non-specificity to tumor cells …

Recent development of pH‐responsive theranostic nanoplatforms for magnetic resonance imaging‐guided cancer therapy

X Li, R Yue, G Guan, C Zhang, Y Zhou, G Song - Exploration, 2023 - Wiley Online Library
The acidic characteristic of the tumor site is one of the most well‐known features and
provides a series of opportunities for cancer‐specific theranostic strategies. In this regard …