Heparanase has been viewed as a promising anti-cancer drug target for almost two
decades, but no anti-heparanase therapy has yet reached the clinic. This endoglycosidase …

Naturally occurring cancers in non-laboratory species have great potential in helping to
decipher the often complex causes of neoplasia. Wild animal models could add substantially …

Background The epigenetic abnormality of tumor-associated genes contributes to the
pathogenesis of colorectal carcinoma (CRC). However, methylation in colorectal cancer is …

Introduction The search for a specific marker that could help to distinguish between
differentiated thyroid carcinoma and benign lesions remains elusive in clinical practice …

Background Endometriosis is a common cause of endometrial-type mucosa outside the
uterine cavity with symptoms such as painful periods, chronic pelvic pain, pain with …

In this chapter, we will emphasize the importance of heparan sulfate proteoglycans (HSPG)
in controlling various physiological and pathological molecular mechanisms and discuss …

Aim: Heparanase-2 expression has been suggested to up-regulate in several types of
human cancers. However, the expression patterns of heparanase-2 in gastric cancer and its …

Several studies reported the concerted and mutual communication between the prostate
epithelium and stroma, which determines the final organ architecture and function, but gets …

Background: The process of proliferation and invasion of tumor cells depends on changes in
the extracellular matrix (ECM) through the activation of enzymes and alterations in the profile …

CONTEXT AND OBJECTIVE: Heparanase-1 degrades heparan sulfate and has been
correlated with tumor progression. Although the isoform heparanase-2 has no catalytic …