Research into the mechanisms and manifestations of solid tumor vascularization was
launched more than 50 years ago with the proposition and experimental demonstrations that …

Tumours display considerable variation in the patterning and properties of angiogenic blood
vessels, as well as in their responses to anti-angiogenic therapy. Angiogenic programming …

Hepatic stellate cells are liver-specific mesenchymal cells that play vital roles in liver
physiology and fibrogenesis. They are located in the space of Disse and maintain close …

Platelet-derived growth factors (PDGF) promotes cell proliferation, survival and migration,
primarily of cells of mesenchymal origin. Dysfunction of PDGF signaling has been observed …

The field of angiogenesis research has primarily focused on the mechanisms of sprouting
angiogenesis. Yet vascular networks formed by vessel sprouting subsequently undergo …

Epigenetic alterations occur in many physiological and pathological processes. N 6-
methyladenosine (m 6 A) modification is the most prevalent modification in eukaryotic …

Retinopathy of prematurity (ROP) is a vasoproliferative disorder of the retina and a leading
cause of visual impairment and childhood blindness worldwide. The disease is …

The four types of platelet-derived growth factors (PDGFs) and the two types of PDGF
receptors (PDGFRs, which belong to class III receptor tyrosine kinases) have important …

Platelet-derived growth factors (PDGFs) and their receptors (PDGFRs) are frequently
expressed in various tumors and their expression levels correlate with tumor growth …

Cancer-associated fibroblasts (CAFs) are the most abundant stromal cells within the tumor
microenvironment (TME). They extensively communicate with the other cells. Exosome …