Cancer is a prominent cause of death globally. Currently, many drugs that are in clinical
practice are having a high prevalence of side effect and multidrug resistance. Risk of tumors …

The biggest challenge associated with cancer chemotherapy is the development of cross
multi-drug resistance to almost all anti-cancer agents upon chronic treatment. The major …

In recent decades, increasing interest in the use of natural products in anticancer therapy
field has been observed, mainly due to unsolved drug-resistance problems. The antitumoral …

Colorectal cancer (CRC), among the most aggressive and prevailing neoplasms, is primarily
treated with chemotherapy. Voacamine (VOA), a novel bisindole natural product, possesses …

In this study, we report on the synthesis of L-Cysteine (L-Cys)-coated magnetic iron oxide
nanoparticles (NPs) loaded with doxorubicin (Dox). The Fe3O4-L-Cys-Dox NPs were …

Doxorubicin is one of the leading drugs for osteosarcoma standard chemotherapy. A total of
40% to 45% of high-grade osteosarcoma patients are unresponsive, or only partially …

Modulation of pH is crucial to maintaining the chemical homeostasis of biological
environments. The irregular metabolic pathways exhibited by cancer cells result in the …

Most women with ovarian cancer are treated with chemotherapy before or after surgery.
Unfortunately, chemotherapy treatment can cause negative side effects and the onset of …

Indole alkaloids possess a large spectrum of biological activities including anti-protozoal
action. Here we report for the first time that voacamine, isolated from the plant …

The current study investigated the role of combination therapy with voacamine and
vincristine in preventing mammary gland carcinoma through prolyl hydroxylase-2 activation …