Control of cell death in health and disease

N Kayagaki, JD Webster… - Annual Review of …, 2024 - annualreviews.org
Apoptosis, necroptosis, and pyroptosis are genetically programmed cell death mechanisms
that eliminate obsolete, damaged, infected, and self-reactive cells. Apoptosis fragments cells …

[HTML][HTML] DNA dioxygenases TET2 deficiency promotes cigarette smoke induced chronic obstructive pulmonary disease by inducing ferroptosis of lung epithelial cell

Z Zeng, T Li, X Liu, Y Ma, L Luo, ZL Wang, Z Zhao, H Li… - Redox Biology, 2023 - Elsevier
Chronic obstructive pulmonary disease (COPD) is a significant global cause of morbidity
and mortality currently. Long-term exposure of cigarette smoke (CS) inducing persistent …

TLR7 promotes smoke-induced experimental lung damage through the activity of mast cell tryptase

G Liu, TJ Haw, MR Starkey, AM Philp, S Pavlidis… - Nature …, 2023 - nature.com
Abstract Toll-like receptor 7 (TLR7) is known for eliciting immunity against single-stranded
RNA viruses, and is increased in both human and cigarette smoke (CS)-induced …

Mitochondria-targeted antioxidants as a therapeutic strategy for chronic obstructive pulmonary disease

LH Fairley, S Das, V Dharwal, N Amorim, KJ Hegarty… - Antioxidants, 2023 - mdpi.com
Oxidative stress is a major hallmark of COPD, contributing to inflammatory signaling,
corticosteroid resistance, DNA damage, and accelerated lung aging and cellular …

Revealing a potential necroptosis‐related axis (RP11‐138A9. 1/hsa‐miR‐98‐5p/ZBP1) in periodontitis by construction of the ceRNA network

Z Wang, H Chen, L Peng, Y He… - Journal of Periodontal …, 2023 - Wiley Online Library
Abstract Background and Objectives Periodontitis, a prevalent chronic inflammatory
condition, poses a significant risk of tooth loosening and subsequent tooth loss. Within the …

RIPK1 inhibitors: A key to unlocking the potential of necroptosis in drug development

Y Bai, Y Qiao, M Li, W Yang, H Chen, Y Wu… - European Journal of …, 2024 - Elsevier
Within the field of medical science, there is a great deal of interest in investigating cell death
pathways in the hopes of discovering new drugs. Over the past two decades …

Targeted Degradation of Receptor-Interacting Protein Kinase 1 to Modulate the Necroptosis Pathway

H Inuzuka, C Qian, Y Qi, Y Xiong, C Wang… - ACS Pharmacology & …, 2024 - ACS Publications
Necroptosis is a highly regulated form of necrotic cell death that plays an essential role in
pathogen defense and tissue homeostasis. Abnormal regulation of the necroptotic pathway …

A narrative review on lung injury: mechanisms, biomarkers, and monitoring

W Fan, B Gui, X Zhou, L Li, H Chen - Critical Care, 2024 - Springer
Lung injury is closely associated with the heterogeneity, severity, mortality, and prognosis of
various respiratory diseases. Effective monitoring of lung injury is crucial for the optimal …

Cell type‐specific molecular mechanisms and implications of necroptosis in inflammatory respiratory diseases

Y Guo, J Zhou, Y Wang, X Wu, Y Mou… - Immunological …, 2024 - Wiley Online Library
Necroptosis is generally considered as an inflammatory cell death form. The core regulators
of necroptotic signaling are receptor‐interacting serine–threonine protein kinases 1 (RIPK1) …

PANoptosis: mechanism and role in pulmonary diseases

S Chen, J Jiang, T Li, L Huang - International Journal of Molecular …, 2023 - mdpi.com
PANoptosis is a newly defined programmed cell death (PCD) triggered by a series of stimuli,
and it engages three well-learned PCD forms (pyroptosis, apoptosis, necroptosis) …