The α2 and β2 adrenergic receptors, both of which are activated by epinephrine, but which
can be differentiated by selective drugs, have opposite effects (inhibitory and stimulatory) on …

The facilitated diffusion of d-glucose across the plasma membrane is carried out by a set of
stereospecific transport proteins known as the glucose transporters. These integral …

The cyclin-dependent kinase CdkP associates with cyclins A, D, and E and has been
implicated in the control of the Gl to S phase transition in mammals. To identify potential …

Homologous or agonist-specific desensitization of β-adrenergic receptors is thought to be
mediated by a specific kinase, the β-adrenergic receptor kinase (βARK). However, recent …

A scalable transfection procedure using polyethylenimine (PEI) is described for the human
embryonic kidney 293 cell line grown in suspension. Green fluorescent protein (GFP) and …

We examined the ability of chemokine receptors and related G protein–coupled receptors to
facilitate infection by primary, clinical HIV-1 isolates. CCR5, when expressed along with …

The pineal hormone melatonin regulates seasonal reproductive function and modulates
circadian rhythms in mammals. We now report the cloning and characterization of a high …

AG protein-coupled receptor for the pineal hormone melatonin was recently cloned from
mammals and designated the Mel1a melatonin receptor. We now report the cloning of a …

β-Arrestins are proteins that bind phosphorylated heterotrimeric GTP-binding protein (G
protein)-coupled receptors (GPCRs) and contribute to the desensitization of GPCRs by …

We have replaced the C-terminal portion of the third intracellular loop of the beta 2-
adrenergic receptor (residues 266-272) with the homologous region of the alpha 1B …