Gliomas are the common type of brain tumors originating from glial cells. Epidemiologically,
gliomas occur among all ages, more often seen in adults, which males are more susceptible …

The immune checkpoint molecule CD70 and its receptor CD27 are aberrantly expressed in
many hematological and solid malignancies. Dysregulation of the CD70-CD27 axis within …

Effective therapeutic strategies are needed for non-small cell lung cancer (NSCLC) patients
with epidermal growth factor receptor (EGFR) mutations that acquire resistance to EGFR …

Hepatocellular carcinoma (HCC) is a major cause of cancer mortality worldwide and
available therapies, including immunotherapies, are ineffective for many patients. HCC is …

Glioblastoma (GB) is the most common and aggressive primary brain tumor in adults and
currently incurable. Despite multimodal treatment regimens, median survival in unselected …

Despite maximal surgical and medical therapy, the treatment of glioblastoma remains a
seriously vexing problem, with median survival well under 2 years and few long-term …

Glioblastoma (GBM) is the most devastating brain tumor, with associated poor prognosis.
Despite advances in surgery and chemoradiation, the survival of afflicted patients has not …

Cancers express a large battery of genes by which they establish an immunosuppressive
tumor microenvironment. Many of these genes are induced by intratumoral hypoxia through …

Simple Summary Certain immune cells, namely T cells, of cancer patients can be genetically
manipulated to express so-called chimeric antigen receptors (CARs), which enables these …

Human glioblastoma is a highly lethal tumor that is known for its immune inhibitory
capabilities. B7-homologue 1 (B7-H1), a recently identified homologue of B7. 1/2 (CD80/86) …