Tumour hypoxia induces a metabolic shift causing acidosis: a common feature in cancer
J Chiche, MC Brahimi‐Horn… - Journal of cellular and …, 2010 - Wiley Online Library
Introduction• Intracellular pH regulation controls energy balance and cell proliferation:
chemical and biological proof of principle‐Chemical proof of principle‐Biological proof of …
chemical and biological proof of principle‐Chemical proof of principle‐Biological proof of …
[HTML][HTML] Recent developments in targeting carbonic anhydrase IX for cancer therapeutics
PC McDonald, JY Winum, CT Supuran, S Dedhar - Oncotarget, 2012 - ncbi.nlm.nih.gov
Carbonic anhydrase IX (CAIX) is a hypoxia-inducible enzyme that is overexpressed by
cancer cells from many tumor types, and is a component of the pH regulatory system …
cancer cells from many tumor types, and is a component of the pH regulatory system …
Hypoxia-regulated carbonic anhydrase IX (CAIX) protein is an independent prognostic indicator in triple negative breast cancer
CHC Ong, DY Lee, B Lee, H Li, JCT Lim, JX Lim… - Breast Cancer …, 2022 - Springer
Background The effect of extracellular microenvironment (hypoxia and pH) has been
regarded as a key hallmark in cancer progression. The study aims to investigate the effects …
regarded as a key hallmark in cancer progression. The study aims to investigate the effects …
[PDF][PDF] MicroRNA‐26a suppresses angiogenesis in human hepatocellular carcinoma by targeting hepatocyte growth factor‐cMet pathway
X Yang, XF Zhang, X Lu, HL Jia, L Liang, QZ Dong… - …, 2014 - Wiley Online Library
MicroRNA (miR)‐26a can suppress tumor growth and metastasis of hepatocellular
carcinoma (HCC). Since angiogenesis is important for tumor growth and metastasis, we …
carcinoma (HCC). Since angiogenesis is important for tumor growth and metastasis, we …
[HTML][HTML] Curcumin inhibits in vitro and in vivo chronic myelogenous leukemia cells growth: a possible role for exosomal disposal of miR-21
S Taverna, M Giallombardo, M Pucci, A Flugy… - Oncotarget, 2015 - ncbi.nlm.nih.gov
Exosomes are nanosize vesicles released from cancer cells containing microRNAs that can
influence gene expression in target cells. Curcumin has been shown to exhibit antitumor …
influence gene expression in target cells. Curcumin has been shown to exhibit antitumor …
The HIF-1–inducible lysyl oxidase activates HIF-1 via the Akt pathway in a positive regulation loop and synergizes with HIF-1 in promoting tumor cell growth
F Pez, F Dayan, J Durivault, B Kaniewski, G Aimond… - Cancer research, 2011 - AACR
Adaptation to hypoxia is a driving force for tumor progression that leads to therapy
resistance and poor clinical outcome. Hypoxic responses are mainly mediated by hypoxia …
resistance and poor clinical outcome. Hypoxic responses are mainly mediated by hypoxia …
Mesenchymal stem cells, as glioma exosomal immunosuppressive signal multipliers, enhance MDSCs immunosuppressive activity through the miR-21/SP1/DNMT1 …
W Qiu, Q Guo, X Guo, C Wang, B Li, Y Qi… - Journal of …, 2023 - Springer
Background The immunosuppressive microenvironment in glioma induces immunotherapy
resistance and is associated with poor prognosis. Glioma-associated mesenchymal stem …
resistance and is associated with poor prognosis. Glioma-associated mesenchymal stem …
Comparative genomics of esophageal adenocarcinoma and squamous cell carcinoma
S Bandla, A Pennathur, JD Luketich, DG Beer… - The Annals of thoracic …, 2012 - Elsevier
BACKGROUND: Esophageal cancer consists of two major histologic types: esophageal
squamous cell carcinoma (ESCC), predominant globally, and esophageal adenocarcinoma …
squamous cell carcinoma (ESCC), predominant globally, and esophageal adenocarcinoma …
[HTML][HTML] Link between PI3K/AKT/PTEN pathway and NOX proteinin diseases
A Nakanishi, Y Wada, Y Kitagishi, S Matsuda - Aging and disease, 2014 - ncbi.nlm.nih.gov
Accumulating evidence has revealed that thePI3K/AKT/PTENpathway acts as a pivotal
determinant of cell fate regarding senescence and apoptosis, which is mediated by …
determinant of cell fate regarding senescence and apoptosis, which is mediated by …
[HTML][HTML] Expression of hypoxia-inducible factor 1α in thyroid carcinomas
N Burrows, J Resch, RL Cowen… - Endocrine-related …, 2010 - ncbi.nlm.nih.gov
Hypoxia-inducible factor 1α (HIF-1α) is upregulated by hypoxia and oncogenic signalling in
many solid tumours. Its regulation and function in thyroid carcinomas are unknown. We …
many solid tumours. Its regulation and function in thyroid carcinomas are unknown. We …