Much has been learned since the early 1960s about histone post-translational modifications
(PTMs) and how they affect DNA-templated processes at the molecular level. This …

Recent studies on mutations in cancer genomes have distinguished driver mutations from
passenger mutations, which occur as byproducts of cancer development. The cancer …

Recent efforts have succeeded in surveying open chromatin at the single-cell level, but high-
throughput, single-cell assessment of heterochromatin and its underlying genomic …

Histone methylation is a key posttranslational modification of chromatin, and its
dysregulation affects a wide array of nuclear activities including the maintenance of genome …

The origin recognition complex (ORC) binds sites from which DNA replication is initiated. We
address ORC binding selectivity in vivo by mapping∼ 52,000 ORC2 binding sites …

Histone methylation plays fundamental roles in regulating chromatin‐based processes. With
the discovery of histone demethylases over a decade ago, it is now clear that histone …

For more than three decades, investigators have sought to identify the precise locations
where DNA replication initiates in mammalian genomes. The development of molecular and …

Background Stroke is a sexually dimorphic disease. Previous studies have found that young
females are protected against ischemia compared to males, partially due to the protective …

Based on experimentally determined average inter-origin distances of~ 100 kb, DNA
replication initiates from~ 50,000 origins on human chromosomes in each cell cycle. The …

Iron accumulation in the substantia nigra is recognized as a hallmark of Parkinson's disease
(PD). Therefore, reducing accumulated iron and associated oxidative stress is considered a …