Epstein-Barr virus: Biology and clinical disease

B Damania, SC Kenney, N Raab-Traub - Cell, 2022 - cell.com
Epstein-Barr virus (EBV) is a ubiquitous, oncogenic virus that is associated with a number of
different human malignancies as well as autoimmune disorders. The expression of EBV viral …

Epigenetic lifestyle of Epstein-Barr virus

A Buschle, W Hammerschmidt - Seminars in immunopathology, 2020 - Springer
Epstein-Barr virus (EBV) is a model of herpesvirus latency and epigenetic changes. The
virus preferentially infects human B-lymphocytes (and also other cell types) but does not turn …

Herpesvirus late gene expression: a viral-specific pre-initiation complex is key

H Gruffat, R Marchione, E Manet - Frontiers in microbiology, 2016 - frontiersin.org
During their productive cycle, herpesviruses exhibit a strictly regulated temporal cascade of
gene expression that can be divided into three general stages: immediate-early (IE), early …

Epigenetic control of the Epstein-Barr lifecycle

R Guo, BE Gewurz - Current opinion in virology, 2022 - Elsevier
Epstein-Barr virus (EBV) infects 95% of adults worldwide, causes infectious mononucleosis,
is etiologically linked to multiple sclerosis and is associated with 200 000 cases of cancer …

[HTML][HTML] Epstein-Barr virus induces host shutoff extensively via BGLF5-independent mechanisms

A Casco, M Ohashi, E Johannsen - Cell reports, 2024 - cell.com
Epstein-Barr virus (EBV) is a ubiquitous oncogenic virus associated with multiple cancers
and autoimmune diseases. Unlike most herpesviruses, EBV reactivation from latency occurs …

ATM, KAP1 and the Epstein–Barr virus polymerase processivity factor direct traffic at the intersection of transcription and replication

H Xu, IA Akinyemi, J Haley, MT McIntosh… - Nucleic Acids …, 2023 - academic.oup.com
The timing of transcription and replication must be carefully regulated for heavily-transcribed
genomes of double-stranded DNA viruses: transcription of immediate early/early genes must …

A temporal proteomic map of Epstein-Barr virus lytic replication in B cells

I Ersing, L Nobre, LW Wang, L Soday, Y Ma, JA Paulo… - Cell reports, 2017 - cell.com
Epstein-Barr virus (EBV) replication contributes to multiple human diseases, including
infectious mononucleosis, nasopharyngeal carcinoma, B cell lymphomas, and oral hairy …

Epstein-Barr virus late gene transcription depends on the assembly of a virus-specific preinitiation complex

V Aubry, F Mure, B Mariamé, T Deschamps… - Journal of …, 2014 - Am Soc Microbiol
During their productive cycle, herpesviruses exhibit a strictly regulated temporal cascade of
gene expression that has three general stages: immediate early (IE), early (E), and late (L) …

SARS-CoV-2 and the DNA damage response

RJ Grand - Journal of General Virology, 2023 - microbiologyresearch.org
The recent coronavirus disease 2019 (COVID-19) pandemic was caused by severe acute
respiratory syndrome coronavirus 2 (SARS-CoV-2). COVID-19 is characterized by …

Reduced IRF4 expression promotes lytic phenotype in Type 2 EBV-infected B cells

JA Bristol, J Brand, M Ohashi, MR Eichelberg… - PloS …, 2022 - journals.plos.org
Humans are infected with two types of EBV (Type 1 (T1) and Type 2 (T2)) that differ
substantially in their EBNA2 and EBNA 3A/B/C latency proteins and have different …