Potential therapeutic agents on alzheimer's disease through molecular docking and molecular dynamics simulation study of plant‐based compounds

K Borah, K Bora, S Mallik, Z Zhao - Chemistry & biodiversity, 2023 - Wiley Online Library
Globally Alzheimer's disease (AD) is a highly complex, heterogeneous, and multifactorial
neurological disease. AD is categorized clinically through a steady loss in memory and …

The neuroprotective effect of ethanolic extract Ocimum sanctum Linn. in the regulation of neuronal density in hippocampus areas as a central autobiography memory …

MBA Mataram, P Hening, FN Harjanti, S Karnati… - Journal of chemical …, 2021 - Elsevier
The aim of this study was to identify the effects of Ocimum sanctum Linn. ethanolic extract
(OSE) on the neurons of the CA1, CA3, and DG hippocampal areas with the use of in vivo …

Trio-drug combination of sodium valproate, baclofen and thymoquinone exhibits synergistic anticonvulsant effects in rats and neuro-protective effects in HEK-293 cells

F Hyder Pottoo, M Salahuddin, FA Khan… - Current issues in …, 2022 - mdpi.com
Epilepsy is a chronic brain disorder, with anti-epileptic drugs (AEDs) providing relief from
hyper-excitability of neurons, but largely failing to restrain neurodegeneration. We …

Ethanolic extract Ocimum sanctum Linn. induces an apoptosis in human lung adenocarcinoma (A549) cells

H Wihadmadyatami, S Karnati, P Hening, Y Tjahjono… - Heliyon, 2019 - cell.com
Ocimum sanctum (OS) is tropical herbal plant which is easy to find and widely used as a
vegetable food in Indonesia. In last decade, lung adenocarcinoma was in top position as …

[HTML][HTML] Herbal Therapeutics for Alzheimer's Disease: Ancient Indian Medicine System from the Modern Viewpoint

S Kushwah, NS Maurya, S Kushwaha… - Current …, 2023 - ncbi.nlm.nih.gov
Alzheimer's is a chronic neurodegenerative disease where amyloid-beta (Aβ) plaques and
neurofibrillary tangles are formed inside the brain. It is also characterized by progressive …

Phytochemicals as therapeutic interventions in neurodegenerative diseases

RV Kavitha, JR Kumar, C Egbuna, JC Ifemeje - Phytochemicals as lead …, 2020 - Elsevier
Neurological disorders are ranked as a leading disorder under the subgroup of disability-
adjusted life years (DALYs) in 2015 under the global burden of diseases and second …

Neuroprotective activity of Indonesian traditional herbal medicine: A systematic review

M Agil, I Kusumawati… - Journal of Applied …, 2023 - repository.uin-malang.ac.id
The brain requires good care for it regulates all systems and functions of the human body's
organs. Good care can also prevent brain damage caused by the ageing process and …

Diosgenin loaded cellulose nanoonion impedes different stages of protein aggregation induced cell death via alleviating mitochondrial dysfunction and upregulation …

SMS Abidi, AK Shukla, S Randhawa, M Bathla… - International Journal of …, 2024 - Elsevier
Protein aggregation is a multifaceted phenomenon prevalent in the progression of
neurodegenerative diseases, yielding aggregates of diverse sizes. Recently, increased …

Neuroprotective and Nootropic Evaluation of some Important Medicinal Plants in Dementia: A Review

FH Shah, YS Eom, KH Lim… - Letters in Drug Design & …, 2024 - ingentaconnect.com
Dementia is a devitalising decline in neurological acuity, which burdens both high-and
lowincome countries due to poor diagnostic systems and high healthcare costs. A growing …

Ocimum sanctum leaves prevent neuronal cell apoptosis through reduction of caspase-3 and-9 expressions and inhibition of β-amyloid oligomerization

D Aliffia, DA Ramadhani, W Wasityastuti… - The Indonesian …, 2023 - inabj.org
BACKGROUND: Neurodegenerative diseases are characterized by the loss of neuronal
function in the nervous system. In recent years, more than 45 million people worldwide have …