This review provides insights on the impact of glycosylation in cancer biology and its
influence in the current approaches of targeted cancer therapies in the clinical setting. The …

During malignant transformation, glycosylation is heavily altered compared with healthy
tissue due to differential expression of glycosyltransferases, glycosidases and …

How disseminated tumour cells engage specific stromal components in distant organs for
survival and outgrowth is a critical but poorly understood step of the metastatic cascade …

Malignant transformation of cells is associated with aberrant glycosylation presented on the
cell-surface. Commonly observed changes in glycan structures during malignancy …

O-glycosylation is a highly frequent post-translation modification of proteins, with important
functional implications in both physiological and disease contexts. The biosynthesis of O …

Despite advances in understanding the development and progression of cancer in recent
years, there remains a lack of comprehensive characterization of the cancer glycoproteome …

Glycosylation is among the most important post-translational modifications for proteins and
is of intrinsic complex character compared with DNAs and naked proteins. Indeed, over 50 …

Fucosylation is a post-translational modification of glycans, proteins, and lipids that is
responsible for many biological processes. Fucose conjugation via α (1, 2), α (1, 3), α (1, 4) …

Prostate cancer is the most commonly diagnosed malignancy in men, claiming over 350,000
lives worldwide annually. Current diagnosis relies on prostate-specific antigen (PSA) testing …

Metastatic disease is the principal cause of prostate-cancer-related mortality. Our ability to
accurately recapitulate the spread of prostate cancer to bone—the most common site of …