TIGIT, the next step towards successful combination immune checkpoint therapy in cancer
T cell immunoreceptor with Ig and ITIM domains (TIGIT) is an inhibitory receptor expressed
on several types of lymphocytes. Efficacy of antibody blockade of TIGIT in cancer …
on several types of lymphocytes. Efficacy of antibody blockade of TIGIT in cancer …
Combination cancer immunotherapy and new immunomodulatory targets
KM Mahoney, PD Rennert, GJ Freeman - Nature reviews Drug …, 2015 - nature.com
Targeting immune checkpoints such as programmed cell death protein 1 (PD1),
programmed cell death 1 ligand 1 (PDL1) and cytotoxic T lymphocyte antigen 4 (CTLA4) has …
programmed cell death 1 ligand 1 (PDL1) and cytotoxic T lymphocyte antigen 4 (CTLA4) has …
TIGIT and PD-1 impair tumor antigen–specific CD8+ T cells in melanoma patients
JM Chauvin, O Pagliano, J Fourcade… - The Journal of …, 2015 - Am Soc Clin Investig
T cell Ig and ITIM domain (TIGIT) is an inhibitory receptor expressed by activated T cells,
Tregs, and NK cells. Here, we determined that TIGIT is upregulated on tumor antigen …
Tregs, and NK cells. Here, we determined that TIGIT is upregulated on tumor antigen …
TIGIT and PD-1 dual checkpoint blockade enhances antitumor immunity and survival in GBM
AL Hung, R Maxwell, D Theodros, Z Belcaid… - …, 2018 - Taylor & Francis
The use of inhibitory checkpoint blockade in the management of glioblastoma has been
studied in both preclinical and clinical settings. TIGIT is a novel checkpoint inhibitor recently …
studied in both preclinical and clinical settings. TIGIT is a novel checkpoint inhibitor recently …
Balancing natural killer cell activation through paired receptors
L Martinet, MJ Smyth - Nature Reviews Immunology, 2015 - nature.com
Natural killer (NK) cells are innate lymphocytes that are crucial for the control of infections
and malignancies. NK cells express a variety of inhibitory and activating receptors that …
and malignancies. NK cells express a variety of inhibitory and activating receptors that …
DNAM-1 and the TIGIT/PVRIG/TACTILE axis: novel immune checkpoints for natural killer cell-based cancer immunotherapy
B Sanchez-Correa, I Valhondo, F Hassouneh… - Cancers, 2019 - mdpi.com
Natural killer (NK) cells are lymphocytes of the innate immune response characterized by
their role in the destruction of tumor cells. Activation of NK cells depend on a fine balance …
their role in the destruction of tumor cells. Activation of NK cells depend on a fine balance …
Tumor cell infiltration into the brain in glioblastoma: from mechanisms to clinical perspectives
Simple Summary The estimated survival time for glioblastoma patients is extremely low; only
about 5% of patients survive five years post diagnosis. The standard of care for glioblastoma …
about 5% of patients survive five years post diagnosis. The standard of care for glioblastoma …
Recognition of tumors by the innate immune system and natural killer cells
A Marcus, BG Gowen, TW Thompson, A Iannello… - Advances in …, 2014 - Elsevier
In recent years, roles of the immune system in immune surveillance of cancer have been
explored using a variety of approaches. The roles of the adaptive immune system have been …
explored using a variety of approaches. The roles of the adaptive immune system have been …
The interaction of TIGIT with PVR and PVRL2 inhibits human NK cell cytotoxicity
N Stanietsky, H Simic, J Arapovic… - Proceedings of the …, 2009 - National Acad Sciences
NK cell cytotoxicity is controlled by numerous NK inhibitory and activating receptors. Most of
the inhibitory receptors bind MHC class I proteins and are expressed in a variegated …
the inhibitory receptors bind MHC class I proteins and are expressed in a variegated …
Molecular pathways: targeting CD96 and TIGIT for cancer immunotherapy
The receptors CD96 and TIGIT are expressed on the surface of T and natural killer (NK)
cells, and recent studies suggest both play important inhibitory roles in immune function …
cells, and recent studies suggest both play important inhibitory roles in immune function …