A growing solid tumor relies on a developing vasculature to meet its needs in terms of
oxygen, nutrients, depuration, etc. This implies that if the vascular bed that has developed …

A number of natural products, with diverse chemical structures, have been isolated as
anticancer agents. Several potential lead molecules such as camptothecin, vincristine …

Microtubules are the basic components of cell structure, which take part in a wide number of
pivotal cellular functions. Drugs that are able to modulate the microtubule assembly either by …

The vital roles of microtubule in mitosis and cell division make it an attractive target for
antitumor therapy. Colchicine binding site of tubulin is one of the most important pockets that …

Modulating the structure and function of tubulin and microtubules is an important route to
anticancer therapeutics, and therefore, small molecules that bind to tubulin and cause …

Natural products (NPs) have played a key role in drug discovery and are still a prolific
source of novel lead compounds or pharmacophores for medicinal chemistry …

The synthesis and study of the structure− activity relationships of two new classes of
synthetic antitubulin compounds based on 1-aroylindole and 3-aroylindole skeletons are …

Cornbretastatin A-4 (CA-4) is one of the most potent antinnitotic and antiangiogenic agents
of natural origin. It has displayed potent antitunnor effect in a wide variety of preclinical …

The combretastatins are isolated from South African tree combretum caffrum kuntze. The
lead compound combretastatin A-4 has displayed remarkable cytotoxic effect in a wide …

The design of novel anticancer agents based on the combretastatins, a group of antimitotic
agents isolated from the bark of the South African willow tree Combretum caffrum Kuntz, is of …