Septins belong to a family of proteins that is highly conserved in eukaryotes and is
increasingly recognized as a novel component of the cytoskeleton. All septins are GTP …

All cells undergo rapid remodeling of their actin networks to regulate such critical processes
as endocytosis, cytokinesis, cell polarity, and cell morphogenesis. These events are driven …

The establishment of cell polarity is critical for the development of many organisms and for
the function of many cell types. A large number of studies of diverse organisms from yeast to …

Most human cells require anchorage for survival. Cell–substrate adhesion activates diverse
signalling pathways, without which cells undergo anoikis—a form of programmed cell death …

Actin-based motility is used by various pathogens for dissemination within and between
cells. Yet host factors restricting this process have not been identified. Septins are GTP …

Abstract Background Septins are cytoskeletal GTPase proteins first discovered in the fungus
Saccharomyces cerevisiae where they organize the septum and link nuclear division with …

Septins are GTP-binding proteins that polymerize into heteromeric filaments and form
microscopic bundles or ring structures in vitro and in vivo. Because of these properties and …

Human septins comprise a family of 13 genes that encode for> 30 protein isoforms with
ubiquitous and tissue-specific expressions. Septins are GTP-binding proteins that assemble …

Septins are GTP-binding proteins that form filaments and higher-order structures on the cell
cortex of eukaryotic cells and associate with actin and microtubule cytoskeletal networks …

Mice lacking the expression of proteolipid protein (PLP)/DM20 in oligodendrocytes provide a
genuine model for spastic paraplegia (SPG-2). Their axons are well myelinated but exhibit …