Bispecific antibodies (BsAbs) are emerging as an important novel class of
immunotherapeutic agents for the treatment of multiple myeloma (MM), and are set to be …

The adaptive immune system has the enormous challenge to protect the host through the
generation and differentiation of pathogen‐specific short‐lived effector T cells while in …

T cell responses are critical for controlling cytomegalovirus (CMV) infection. However, CMV
expresses immune evasion genes promoting escape from T cell immunity. Furthermore …

Cytomegalovirus (CMV) latent infection and aging contribute to alterations in the function
and phenotype of the T-cell pool. We have demonstrated that CMV-seropositivity is …

A better understanding of the complex interactions between the immune system and tumour
cells from different origins has opened the possibility to design novel procedures of …

Highlights•Human cytomegalovirus (HCMV) infection and HCMV-seropositivity have an age-
dependent impact on health and disease.•HCMV is associated with adverse health …

HIV infection is associated with an increase in the proportion of activated CD8+ memory T
cells (Tmem) that express CX3CR1, but how these cells are generated and maintained in …

Background Belatacept, an inhibitor of the CD28-CD80/86 costimulatory pathway, allows for
calcineurin-inhibitor free immunosuppressive therapy in kidney transplantation but is …

Understanding how the T cell memory response directed towards human cytomegalovirus
(HCMV) develops and changes over time while the virus persists is important. Whilst HCMV …

Cytomegalovirus (CMV) is one of the most commonly recognized opportunistic pathogens
and remains the most influential known parameter in shaping an individual's immune …