The comprehensive analysis identified an autophagy signature for the prognosis and the immunotherapy efficiency prediction in lung adenocarcinoma

X Li, Z Dai, X Wu, N Zhang, H Zhang, Z Wang… - Frontiers in …, 2022 - frontiersin.org
Background Lung adenocarcinoma (LUAD) is a fatal malignancy in the world. Growing
evidence demonstrated that autophagy-related genes regulated the immune cell infiltration …

Targeting dysregulated phago-/auto-lysosomes in Sertoli cells to ameliorate late-onset hypogonadism

Z Deng, L Zhao, S Li, X Chen, X Ling, J Zheng, K Yu… - Nature Aging, 2024 - nature.com
Age-related changes in testicular function can impact health and well-being. The
mechanisms underlying age-related testicular dysfunction, such as late-onset …

[HTML][HTML] Plumbagin has an inhibitory effect on the growth of TSCC PDX model and it enhances the anticancer efficacy of cisplatin

Y Xin, Q Jiang, C Liu, J Qiu - Aging (Albany NY), 2023 - ncbi.nlm.nih.gov
Background: Head and neck squamous cell carcinomas are the sixth most common
malignant tumors worldwide. Tongue squamous cell carcinoma is a common malignant …

ARHGAP4 promotes leukemogenesis in acute myeloid leukemia by inhibiting DRAM1 signaling

Y Qi, M Hu, C Han, J Wang, F Chen, H Guo, Y She… - Oncogene, 2023 - nature.com
Rho GTPase-activating protein 4 (ARHGAP4) is an important Rho family GTPase-activating
protein that is strongly associated with the onset and progression of some tumors. We found …

The p53 target DRAM1 modulates calcium homeostasis and ER stress by promoting contact between lysosomes and the ER through STIM1

X Wang, J Geng, S Rimal, Y Sui, J Pan, Z Qin… - Proceedings of the …, 2024 - pnas.org
It is well established that DNA Damage Regulated Autophagy Modulator 1 (DRAM1), a
lysosomal protein and a target of p53, participates in autophagy. The cellular functions of …

Network pharmacology combined with experimental verification to explore the potential mechanism of naringenin in the treatment of cervical cancer

J Zhou, H Li, B Wu, L Zhu, Q Huang, Z Guo, Q He… - Scientific Reports, 2024 - nature.com
Cervical cancer is the second leading cause of morbidity and mortality in women worldwide.
Traditional treatment methods have become limited. Naringenin, a flavonoid abundant in …

Development of a seven-gene tumor immune microenvironment prognostic signature for high-risk grade III endometrial cancer

M Zheng, Y Hu, R Gou, S Li, X Nie, X Li, B Lin - Molecular Therapy …, 2021 - cell.com
Uterine corpus endometrial carcinoma locally infiltrates numerous immune cells and other
tumor immune microenvironment components. These cells are involved in malignant tumor …

Integrative analysis of ex vivo studies and microarray reveals the novel inhibitor effects of trehalose on the pathogenesis of pterygium

Y Durkal, K İnci, O Tokgun, U Yilmaz… - Chemical Biology & …, 2024 - Wiley Online Library
Pterygium is a frequent eye surface condition that is characterized by a high rate of
proliferation, fibrovascular development, cellular migration, corneal infiltration, and …

Xenophagy receptors Optn and p62 and autophagy modulator Dram1 independently promote the zebrafish host defense against Mycobacterium marinum

J Xie, AH Meijer - Frontiers in Cellular and Infection Microbiology, 2024 - frontiersin.org
Anti-bacterial autophagy, also known as xenophagy, is a crucial innate immune process that
helps maintain cellular homeostasis by targeting invading microbes. This defense pathway …

EGFR‐AS1 Promotes Nonsmall Cell Lung Cancer (NSCLC) Progression via Downregulating the miR‐524‐5p/DRAM1 Axis and Inhibiting Autophagic Lysosomal …

Y Xue, J Zhang, J Hou, X Wang - Journal of Oncology, 2022 - Wiley Online Library
Nonsmall cell lung cancer (NSCLC) accounts for the majority of lung cancers. Studies have
revealed the regulatory role of lncRNAs in cancer pathogenesis and their potential use as …