Role of epithelial sodium channel-related inflammation in human diseases

Y Chen, X Yu, Z Yan, S Zhang, J Zhang… - Frontiers in …, 2023 - frontiersin.org
The epithelial sodium channel (ENaC) is a heterotrimer and is widely distributed throughout
the kidneys, blood vessels, lungs, colons, and many other organs. The basic role of the …

Proteolytic activation of the epithelial Sodium Channel (ENaC): Its mechanisms and implications

M Aufy, AM Hussein, T Stojanovic, CR Studenik… - International Journal of …, 2023 - mdpi.com
Epithelial sodium channel (ENaC) are integral to maintaining salt and water homeostasis in
various biological tissues, including the kidney, lung, and colon. They enable the selective …

Aldosterone antagonism is more effective at reducing blood pressure and excessive renal ENaC activity in AngII-infused female rats than in males

V Buncha, A Cherezova, S Alexander… - …, 2023 - Am Heart Assoc
BACKGROUND: AngII (angiotensin II)-dependent hypertension causes comparable
elevations of blood pressure (BP), aldosterone levels, and renal ENaC (epithelial Na+ …

Impact of Enniatin B and Beauvericin on lysosomal Cathepsin B secretion and apoptosis induction

M Aufy, RF Abdelaziz, AM Hussein, N Topcagic… - International Journal of …, 2023 - mdpi.com
Enniatin B (ENN B) and Beauvericin (BEA) are cyclohexadepsipeptides that can be isolated
from Fusarium and Beauveria bassiana, respectively. Both compounds are cytotoxic and …

Enhancement of Radiation Sensitivity by Cathepsin L Suppression in Colon Carcinoma Cells

RF Abdelaziz, AM Hussein, MH Kotob, C Weiss… - International Journal of …, 2023 - mdpi.com
Cancer is one of the main causes of death globally. Radiotherapy/Radiation therapy (RT) is
one of the most common and effective cancer treatments. RT utilizes high-energy radiation …

[HTML][HTML] Design, synthesis, and lead optimization of piperazinyl-pyrimidine analogues as potent small molecules targeting the viral capping machinery of Chikungunya …

V Battisti, J Moesslacher, R Abdelnabi… - European Journal of …, 2024 - Elsevier
The worldwide re-emerge of the Chikungunya virus (CHIKV), the high morbidity associated
with it, and the lack of an available vaccine or antiviral treatment make the development of a …

[HTML][HTML] A narrative review: research progress on the genetic background of neonatal hyperkalemia

W Liang, L Hu - Pediatric Medicine, 2024 - pm.amegroups.org
Methods: The studies were retrieved from PubMed, Ovid-Medline, Web of Science, China
National Knowledge Infrastructure and Wanfang using the title/abstract terms …