The heme oxygenase (HO) enzyme system catabolizes heme to carbon monoxide (CO),
ferrous iron, and biliverdin-IXα (BV), which is reduced to bilirubin-IXα (BR) by biliverdin …

Heme-oxygenase is the enzyme responsible for degradation of endogenous iron
protoporphyirin heme; it catalyzes the reaction's rate-limiting step, resulting in the release of …

Reactive oxygen species (ROS) are generated as by-products of normal cellular metabolic
activities. Superoxide dismutase, glutathione peroxidase, and catalase are the enzymes …

Heme oxygenase catalyzes the rate-limiting step in heme degradation in order to generate
biliverdin, carbon monoxide (CO), and iron. The inducible form of the enzyme, heme …

Abstract The European Cooperation in Science and Technology (COST) provides an ideal
framework to establish multi-disciplinary research networks. COST Action BM1203 (EU …

Parkinson's disease (PD) is a complex neurodegenerative disorder featuring both motor and
nonmotor symptoms associated with a progressive loss of dopaminergic neurons in the …

The heme oxygenase-1 (HO-1) enzyme system remains an attractive therapeutic target for
the treatment of inflammatory conditions. HO-1, a cellular stress protein, serves a vital …

The iron storage protein, ferritin, plays a key role in iron metabolism. Its ability to sequester
the element gives ferritin the dual functions of iron detoxification and iron reserve. The …

This review focuses on the role of oxidative processes in atherosclerosis and its resultant
cardiovascular events. There is now a consensus that atherosclerosis represents a state of …

Heme oxygenases (HO) catabolize free heme, that is, iron (Fe) protoporphyrin (IX), into
equimolar amounts of Fe2+, carbon monoxide (CO), and biliverdin. The stress-responsive …