Discoidin domain receptor tyrosine kinases: new players in cancer progression
RR Valiathan, M Marco, B Leitinger, CG Kleer… - Cancer and Metastasis …, 2012 - Springer
Almost all human cancers display dysregulated expression and/or function of one or more
receptor tyrosine kinases (RTKs). The strong causative association between altered RTK …
receptor tyrosine kinases (RTKs). The strong causative association between altered RTK …
Extracellular matrix component signaling in cancer
HAB Multhaupt, B Leitinger, D Gullberg… - Advanced drug delivery …, 2016 - Elsevier
Cell responses to the extracellular matrix depend on specific signaling events. These are
important from early development, through differentiation and tissue homeostasis, immune …
important from early development, through differentiation and tissue homeostasis, immune …
Targeting Discoidin Domain Receptors DDR1 and DDR2 overcomes matrix‐mediated tumor cell adaptation and tolerance to BRAF‐targeted therapy in melanoma
I Berestjuk, M Lecacheur, A Carminati… - EMBO Molecular …, 2022 - embopress.org
Resistance to BRAF/MEK inhibitor therapy in BRAFV600‐mutated advanced melanoma
remains a major obstacle that limits patient benefit. Microenvironment components including …
remains a major obstacle that limits patient benefit. Microenvironment components including …
Discoidin domain receptors: potential actors and targets in cancer
H Rammal, C Saby, K Magnien, L Van-Gulick… - Frontiers in …, 2016 - frontiersin.org
The extracellular matrix critically controls cancer cell behavior by inducing several signaling
pathways through cell membrane receptors. Besides conferring structural properties to …
pathways through cell membrane receptors. Besides conferring structural properties to …
Mesenchymal stem cell-induced DDR2 mediates stromal-breast cancer interactions and metastasis growth
ME Gonzalez, EE Martin, T Anwar, C Arellano-Garcia… - Cell reports, 2017 - cell.com
Increased collagen deposition by breast cancer (BC)-associated mesenchymal
stem/multipotent stromal cells (MSC) promotes metastasis, but the mechanisms are …
stem/multipotent stromal cells (MSC) promotes metastasis, but the mechanisms are …
PKLR promotes colorectal cancer liver colonization through induction of glutathione synthesis
Colorectal cancer metastasis to the liver is a major cause of cancer-related death; however,
the genes and pathways that govern this metastatic colonization event remain poorly …
the genes and pathways that govern this metastatic colonization event remain poorly …
Discoidin domain receptor 2 (DDR2) promotes breast cancer cell metastasis and the mechanism implicates epithelial–mesenchymal transition programme under …
A wide range of genes involved in breast cancer metastasis have been reported to be
related to the microenvironment. We studied the role of discoidin domain receptor 2 (DDR2) …
related to the microenvironment. We studied the role of discoidin domain receptor 2 (DDR2) …
Complex roles of discoidin domain receptor tyrosine kinases in cancer
Discoidin domain receptors, DDR1 and DDR2 are members of the receptor tyrosine kinase
(RTK) family that serves as a non-integrin collagen receptor and were initially identified as …
(RTK) family that serves as a non-integrin collagen receptor and were initially identified as …
Multitasking discoidin domain receptors are involved in several and specific hallmarks of cancer
Discoidin domain receptors, DDR1 and DDR2, are two members of collagen receptor family
that belong to tyrosine kinase receptor subgroup. Unlike other matrix receptor-like integrins …
that belong to tyrosine kinase receptor subgroup. Unlike other matrix receptor-like integrins …
Small Molecule Discoidin Domain Receptor Kinase Inhibitors and Potential Medical Applications: Miniperspective
Discoidin domain receptors (DDRs) are members of the transmembrane receptor tyrosine
kinase (RTK) superfamily which are distinguished from others by the presence of a discoidin …
kinase (RTK) superfamily which are distinguished from others by the presence of a discoidin …