Familial hypercholesterolaemia

JC Defesche, SS Gidding, M Harada-Shiba… - Nature reviews Disease …, 2017 - nature.com
Familial hypercholesterolaemia is a common inherited disorder characterized by abnormally
elevated serum levels of low-density lipoprotein (LDL) cholesterol from birth, which in time …

Familial hypercholesterolaemia: evolving knowledge for designing adaptive models of care

GF Watts, SS Gidding, P Mata, J Pang… - Nature Reviews …, 2020 - nature.com
Optimal care for familial hypercholesterolaemia (FH) requires patient-centred management,
multidisciplinary teamwork, involvement of primary care practitioners, patient networks …

Reducing the clinical and public health burden of familial hypercholesterolemia: a global call to action

KA Wilemon, J Patel, C Aguilar-Salinas… - JAMA …, 2020 - jamanetwork.com
Importance Familial hypercholesterolemia (FH) is an underdiagnosed and undertreated
genetic disorder that leads to premature morbidity and mortality due to atherosclerotic …

Overview of the current status of familial hypercholesterolaemia care in over 60 countries-The EAS Familial Hypercholesterolaemia Studies Collaboration (FHSC)

AJ Vallejo-Vaz, M De Marco, CAT Stevens, A Akram… - Atherosclerosis, 2018 - Elsevier
Background and aims Management of familial hypercholesterolaemia (FH) may vary across
different settings due to factors related to population characteristics, practice, resources …

Familial hypercholesterolemia: the most frequent cholesterol metabolism disorder caused disease

A Benito-Vicente, KB Uribe, S Jebari… - International journal of …, 2018 - mdpi.com
Cholesterol is an essential component of cell barrier formation and signaling transduction
involved in many essential physiologic processes. For this reason, cholesterol metabolism …

[HTML][HTML] Integrated guidance for enhancing the care of familial hypercholesterolaemia in Australia

GF Watts, DR Sullivan, DL Hare, KM Kostner… - Heart, Lung and …, 2021 - Elsevier
Familial hypercholesterolaemia (FH) is a dominant and highly penetrant monogenic
disorder present from birth that markedly elevates plasma low-density lipoprotein (LDL) …

Global perspective of familial hypercholesterolaemia: a cross-sectional study from the EAS Familial Hypercholesterolaemia Studies Collaboration (FHSC)

AJ Vallejo-Vaz, CAT Stevens, ARM Lyons… - The Lancet, 2021 - thelancet.com
Summary Background The European Atherosclerosis Society Familial
Hypercholesterolaemia Studies Collaboration (FHSC) global registry provides a platform for …

[HTML][HTML] Coronary heart disease mortality in treated familial hypercholesterolaemia: update of the UK Simon Broome FH register

SE Humphries, JA Cooper, M Seed, N Capps… - Atherosclerosis, 2018 - Elsevier
Background and aims Patients with familial hypercholesterolaemia (FH) have an elevated
risk of coronary heart disease (CHD). Here we compare changes in CHD mortality in …

[HTML][HTML] Simplified Canadian definition for familial hypercholesterolemia

I Ruel, D Brisson, S Aljenedil, Z Awan, A Baass… - Canadian Journal of …, 2018 - Elsevier
Familial hypercholesterolemia (FH) is an autosomal codominant lipoprotein disorder
characterized by elevated low-density lipoprotein cholesterol (LDL-C) and high risk of …

Local acetaldehyde—an essential role in alcohol-related upper gastrointestinal tract carcinogenesis

MT Nieminen, M Salaspuro - Cancers, 2018 - mdpi.com
The resident microbiome plays a key role in exposure of the upper gastrointestinal (GI) tract
mucosa to acetaldehyde (ACH), a carcinogenic metabolite of ethanol. Poor oral health is a …