[HTML][HTML] Лекарственные пептидные препараты: прошлое, настоящее, будущее

ВХ Хавинсон - Клиническая медицина, 2020 - cyberleninka.ru
В обзоре представлены данные о зарубежных препаратах, созданных на основе
полипептидов, выделенных из различных органов животных. Эти препараты положили …

[HTML][HTML] Peptide regulation of gene expression: A systematic review

VK Khavinson, IG Popovich, NS Linkova, ES Mironova… - Molecules, 2021 - mdpi.com
Peptides are characterized by their wide range of biological activity: they regulate functions
of the endocrine, nervous, and immune systems. The mechanism of such action of peptides …

Systematic search for structural motifs of peptide binding to double-stranded DNA

N Kolchina, V Khavinson, N Linkova… - Nucleic Acids …, 2019 - academic.oup.com
A large variety of short biologically active peptides possesses antioxidant, antibacterial,
antitumour, anti-ageing and anti-inflammatory activity, involved in the regulation of neuro …

Effect of short peptides on neuronal differentiation of stem cells

S Caputi, O Trubiani, B Sinjari… - International journal …, 2019 - journals.sagepub.com
It has been demonstrated that short peptides play an important role in the transmission of
biological information, modulation of transcription, and restoring genetically conditioned …

Peptide regulation of cell differentiation

V Khavinson, N Linkova, A Diatlova… - Stem Cell Reviews and …, 2020 - Springer
Short peptides are molecules with small molecular weight, capable of penetrating the cell
membrane and nuclear membrane for epigenetic regulation of gene expression, including …

Peptide medicines: past, present, future

VK Khavinson - Clinical Medicine (Russian Journal), 2020 - clinmedjournal.com
This review provides research data on drugs made on the basis of polypeptides isolated
from different animal organs. They initiated the development of drugs of a peptide origin …

[HTML][HTML] Neuroepigenetic mechanisms of action of ultrashort peptides in Alzheimer's disease

A Ilina, V Khavinson, N Linkova… - International Journal of …, 2022 - mdpi.com
Epigenetic regulation of gene expression is necessary for maintaining higher-order
cognitive functions (learning and memory). The current understanding of the role of …

[HTML][HTML] AEDG Peptide (Epitalon) stimulates gene expression and protein synthesis during neurogenesis: possible epigenetic mechanism

V Khavinson, F Diomede, E Mironova, N Linkova… - Molecules, 2020 - mdpi.com
It was shown that AEDG peptide (Ala-Glu-Asp-Gly, Epitalon) regulates the function of the
pineal gland, the retina, and the brain. AEDG peptide increases longevity in animals and …

[PDF][PDF] Neuroprotective effect of EDR peptide in mouse model of Huntington's disease

V Khavinson, N Linkova, E Kukanova… - J. Neurol …, 2017 - pdfs.semanticscholar.org
Huntington's disease (HD) is a fatal, inherited neurodegenerative disorder. The study in
functioning and aging of neurons may give an opportunity to regulate these processes …

Молекулярные механизмы снижения функциональной активности клеток кожи при ее старении

ВХ Хавинсон, НС Линькова, ЕО Куканова… - Успехи …, 2016 - elibrary.ru
В обзоре рассматривается пул сигнальных молекул, регулирующих функциональную
активность клеток кожи. Молекулами апоптоза и старения клеток кожи являются p53 …