Pharmacology and therapeutic implications of current drugs for type 2 diabetes mellitus

AA Tahrani, AH Barnett, CJ Bailey - Nature Reviews Endocrinology, 2016 - nature.com
Type 2 diabetes mellitus (T2DM) is a global epidemic that poses a major challenge to health-
care systems. Improving metabolic control to approach normal glycaemia (where practical) …

Exercise is the real polypill

C Fiuza-Luces, N Garatachea, NA Berger… - Physiology, 2013 - journals.physiology.org
The concept of a “polypill” is receiving growing attention to prevent cardiovascular disease.
Yet similar if not overall higher benefits are achievable with regular exercise, a drug-free …

β cell dysfunction versus insulin resistance in the pathogenesis of type 2 diabetes in East Asians

D Yabe, Y Seino, M Fukushima, S Seino - Current diabetes reports, 2015 - Springer
Abstract Type 2 diabetes (T2DM) is one of the most serious global health problems and is
mainly a result of the drastic increase in East Asia, which includes over a fourth of the global …

Glucose‐dependent insulinotropic polypeptide and glucagon‐like peptide‐1: incretin actions beyond the pancreas

Y Seino, D Yabe - Journal of diabetes investigation, 2013 - Wiley Online Library
Glucose‐dependent insulinotropic polypeptide (GIP) and glucagon‐like peptide‐1 (GLP‐1)
are the two primary incretin hormones secreted from the intestine on ingestion of various …

DPP4 in cardiometabolic disease: recent insights from the laboratory and clinical trials of DPP4 inhibition

J Zhong, A Maiseyeu, SN Davis… - Circulation …, 2015 - Am Heart Assoc
The discovery of incretin-based medications represents a major therapeutic advance in the
pharmacological management of type 2 diabetes mellitus (T2DM), as these agents avoid …

Differences in the HbA1c‐lowering efficacy of glucagon‐like peptide‐1 analogues between Asians and non‐Asians: a systematic review and meta‐analysis

YG Kim, S Hahn, TJ Oh, KS Park… - Diabetes, Obesity and …, 2014 - Wiley Online Library
Aims To compare the HbA1c‐lowering efficacy of glucagon‐like peptide‐1 (GLP‐1)
analogues between Asians and non‐Asians with type 2 diabetes. Methods We searched …

Dipeptidyl peptidase-4 inhibitors for the treatment of type 2 diabetes: comparison, efficacy and safety

CF Deacon, JJ Holst - Expert opinion on pharmacotherapy, 2013 - Taylor & Francis
Introduction: Dipeptidyl peptidase (DPP)-4 inhibitors belong to one class of drugs that have
been approved for treatment of type 2 diabetes (T2D) based on the glucose-lowering actions …

A review of gliptins for 2014

AJ Scheen - Expert opinion on pharmacotherapy, 2015 - Taylor & Francis
Introduction: Dipeptidyl peptidase-4 (DPP-4) inhibitors (gliptins) occupy an increasing place
in the armamentarium of drugs used for the management of hyperglycaemia and offer new …

[HTML][HTML] Tirzepatide: a novel, once-weekly dual GIP and GLP-1 receptor agonist for the treatment of type 2 diabetes

S Kaneko - touchREVIEWS in Endocrinology, 2022 - ncbi.nlm.nih.gov
Gastrointestinal hormones are currently used to treat type 2 diabetes mellitus (T2D). Incretin
preparations with gastric inhibitory polypeptide (GIP) activity or glucagon-like peptide-1 …

Cardiovascular effects of dipeptidyl peptidase-4 inhibitors: from risk factors to clinical outcomes

AJ Scheen - Postgraduate medicine, 2013 - Taylor & Francis
Abstract Dipeptidyl peptidase-4 (DPP-4) inhibitors (gliptins) are oral incretin-based glucose-
lowering agents with proven efficacy and safety in the management of type 2 diabetes …