Responding to the increased popularity of herbal medicines and other forms of
complementary or alternative medicine world-wide, this reference reviews and evaluates …

The importance of plasma protein binding (PPB) in modulating the effective drug
concentration at pharmacological target sites has been the topic of significant discussion …

Herbs are often administered in combination with therapeutic drugs, raising the potential of
herb-drug interactions. An extensive review of the literature identified reported herb-drug …

Tacrolimus (FK506) and cyclosporine (cyclosporin A, CsA) are cornerstone
immunosuppressive agents administered to solid organ transplant recipients to prevent and …

Despite a lower content of many drug metabolising enzymes in the intestinal epithelium
compared to the liver (eg intestinal CYP3A abundance in the intestine is 1% that of the liver) …

The calcineurin inhibitors (CNIs) tacrolimus and cyclosporine are widely used
immunosuppressive drugs characterized by high pharmacokinetic and pharmacodynamic …

There is a worldwide increasing use of herbs which are often administered in combination
with therapeutic drugs, raising the potential for herb-drug interactions. St John's wort …

It is estimated that more than 40% of new chemical entities (NCEs) coming out of the current
drug discovery process have poor biopharmaceutical properties, such as low aqueous …

Methods. We used data from the Australian and New Zealand Dialysis and Transplant
(ANZDATA) Registry to examine the relationships between body mass index (BMI, classified …

St. John's wort, known botanically as Hypericum perforatum, is a sprawling, leafy herb that
grows in open, disturbed areas throughout much of temperate North America and Australia …