Single nucleotide polymorphisms in the cannabinoid CB2 receptor: Molecular pharmacology and disease associations

T Foyzun, M Whiting, KK Velasco… - British Journal of …, 2024 - Wiley Online Library
Preclinical evidence implicating cannabinoid receptor 2 (CB2) in various diseases has led
researchers to question whether CB2 genetics influence aetiology or progression …

Side‐chain dynamics of the α1B‐adrenergic receptor determined by NMR via methyl relaxation

C Baumann, WC Chiang, R Valsecchi, S Jurt… - Protein …, 2023 - Wiley Online Library
G protein‐coupled receptors (GPCRs) are medically important membrane proteins that
sample inactive, intermediate, and active conformational states characterized by relatively …

Analysis of histomorphology and SERNINA5 gene expression in different regions of epididymis of cattleyak

H Li, C Pan, Y Wang, J Li, Z Zhang, K Shahzad… - Journal of Molecular …, 2024 - Springer
The molecular mechanism of sterility in cattleyak is still unresolved. The related factors of
infertility in cattleyak were studied by tissue section, SERPINA5 gene cloning and …

Importance of isoleucine residue in ion channel formation ability of 11-residue peptaibols

T Nakatani, A Koga, S Goto, M Inoue… - Bioorganic & Medicinal …, 2024 - Elsevier
Peptaibols are a class of short peptides, typically 7 to 20 amino acids long, characterized by
noncanonical amino acid residues such as aminoisobutyric acid (Aib). Although the helix …

Co-localization and co-expression of Olfml3 with Iba1 in brain of mice

H Yadav, A Bakshi, V Singh, P Paul… - Journal of …, 2024 - Elsevier
Olfml3 is a microglia-specific protein whose role in neuroinflammation is elusive. In silico
analysis was conducted to characterize the Olfml3 protein, followed by molecular docking …

De Novo Design and Characterization of Novel Antimicrobial Peptides, Lk3 and Lk4, Containing Repeating Unit

M Koshki, P Farrokh - International Journal of Peptide Research and …, 2024 - Springer
Background Short cationic antimicrobial peptides (AMPs) have an excellent potential for
treating various infections. Methods This study focused on the de novo design of two …

Previously uncharacterized aliphatic amino acid positions modulate the apparent catalytic activity of the EAL domain of ZMO_1055 and other cyclic di-GMP specific …

L Cao, YF Yang, F Bai, U Römling - bioRxiv, 2024 - biorxiv.org
The ubiquitous second messenger cyclic di-GMP is the most abundant diffusible nucleotide
signalling system in bacteria deciding the life style transition between sessility and motility …