Schizophrenia (SZ) is a brain disorder that has been intensively studied for over a century;
yet, its etiology and multifactorial pathophysiology remain a puzzle. However, significant …

The so-called reactive oxygen species (ROS) are defined as oxygen-containing species that
are more reactive than O 2 itself, which include hydrogen peroxide and superoxide …

Abstract Cerebral deposition of amyloid β-peptide (Aβ) in the brain is an invariant feature of
Alzheimer's disease (AD). A consistent protective effect of wine consumption on AD has …

Parkinson's disease (PD) is the second-leading cause of dementia and is characterized by a
progressive loss of dopaminergic neurons in the substantia nigra alongside the presence of …

Inhibition of the accumulation of amyloid β-peptide (Aβ) and the formation of β-amyloid fibrils
(fAβ) from Aβ, as well as the destabilization of preformed fAβ in the CNS would be attractive …

Inhibition of the formation of β-amyloid fibrils (fAβ), as well as the destabilization of
preformed fAβ in the CNS, would be attractive therapeutic targets for the treatment of …

Mitochondria are multifunctional and dynamic organelles deeply integrated into cellular
physiology and metabolism. Disturbances in mitochondrial function are involved in several …

Alzheimer's disease (AD) is one of the most common dementing disorders and has profound
medical and social consequences. The initiating molecular event is unknown, and its …

In order to identify the properties of nicotine in relation to oxidative stress or neuroprotection,
differentiated PC12 cells were treated with nicotine, beta-amyloid peptide (Aβ25–35), free …

In addition to evidence that inhalation of ambient particulate matter (PM) can increase
cardiopulmonary morbidity and mortality, the brain may also constitute a site adversely …