The melatonin receptor agonist agomelatine protects against acute pancreatitis induced by cadmium by attenuating inflammation and oxidative stress and modulating …

RS Alruhaimi, EHM Hassanein, MK Abd El-Aziz… - International …, 2023 - Elsevier
Pancreatitis is a serious effect of the heavy metal cadmium (Cd) and inflammation and
oxidative stress (OS) are implicated in Cd-induced pancreatic injury. This study evaluated …

Dapsone Ameliorates Isoproterenol-Induced Myocardial Infarction via Nrf2/ HO-1; TLR4/ TNF-α Signaling Pathways and the Suppression of Oxidative Stress …

WY Abdelzaher, SM Ahmed, NN Welson… - Frontiers in …, 2021 - frontiersin.org
Myocardial infarction (MI) is a critical condition that can happen with high doses or rapid
termination of beta blockers therapy. The study aimed to evaluate the potential anti-toxic …

Agomelatine prevents gentamicin nephrotoxicity by attenuating oxidative stress and TLR-4 signaling, and upregulating PPARγ and SIRT1

AM Mahmoud, OAM Abd El-Ghafar, MA Alzoghaibi… - Life Sciences, 2021 - Elsevier
Kidney injury is a relatively common complication of the use of aminoglycosides.
Inflammation and oxidative stress play a key role in gentamicin (GM) nephrotoxicity. We …

Cadmium cardiotoxicity is associated with oxidative stress and upregulated TLR-4/NF-kB pathway in rats; protective role of agomelatine

RS Alruhaimi, EHM Hassanein, MN Bin-Jumah… - Food and Chemical …, 2023 - Elsevier
Cardiotoxicity is one of the hazardous effects of the exposure to the heavy metal cadmium
(Cd). Inflammation and oxidative injury are implicated in the cardiotoxic mechanism of Cd …

[Retracted] Cardioprotective Activity of Cassia fistula L. Bark Extract in Isoproterenol‐Induced Myocardial Infarction Rat Model

AS Kushwah, R Mittal, M Kumar, G Kaur… - Evidence‐Based …, 2022 - Wiley Online Library
Cassia fistula Linn, generally recognized as Indian laburnum, is one of the ancient trees in
the Indian subcontinent used for its ornamental and diverse medicinal properties. It is known …

Agomelatine ameliorates cadmium-induced toxicity through the modification of HMGB-1/TLR-4/NFκB pathway

HM Hafez, S Waz, NFG El-Tahawy… - Toxicology and Applied …, 2022 - Elsevier
Cadmium (Cd) has potential hazards on human beings. Consequently, this study was
performed to explore the protective effects of agomelatine (AGO), a melatonin receptor …

Generation of cardiomyocytes from stem cells cultured on nanofibrous scaffold: Experimental approach for attenuation of myocardial infarction

HA Aglan, HH Ahmed, HH Beherei, BM Abdel-Hady… - Tissue and Cell, 2024 - Elsevier
The current study was constructed to fabricate polyamide based nanofibrous scaffolds (NS)
and to define the most promising one for the generation of cardiomyocytes from adipose …

[HTML][HTML] Rutin-Activated Nuclear Factor Erythroid 2-Related Factor 2 (Nrf2) Attenuates Corneal and Heart Damage in Mice

PM Emeka, LI Badger-Emeka… - Pharmaceuticals, 2024 - mdpi.com
Background: Corneal degeneration is a form of progressive cell death caused by multiple
factors, such as diabetic retinopathy. It is the most well-known neural degenerative disease …

Sirt1/Nrf2/TNFα; TLR4/Myd88/NF-κB signaling pathways are involved in mediating hepatoprotective effect of bupropion in rat model of myocardial infarction

WY Abdelzaher, A Geddawy, ME Attya… - …, 2024 - Taylor & Francis
Background The aim of the current study is to identify the possible protective effect of
bupropion (BUP) on liver injury in rat model of myocardial infarction (MI). BUP was …

Melatonin Improves Nitric Oxide Bioavailability in Isoproterenol Induced Myocardial Injury

R Santos, P Turck, V de Mello Palma, F Visioli… - Molecular and Cellular …, 2024 - Elsevier
Isoproterenol administration is associated with cardiac inflammation and decreased NO
availability. Melatonin has been reported to have cardioprotective effect. The aim of this …