Protein arginine methyltransferases and cancer

Y Yang, MT Bedford - Nature Reviews Cancer, 2013 - nature.com
There are nine protein arginine methyltransferases (PRMTs) encoded in mammalian
genomes, the protein products of which catalyse three types of arginine methylation …

P-bodies and stress granules: possible roles in the control of translation and mRNA degradation

CJ Decker, R Parker - Cold Spring Harbor perspectives …, 2012 - cshperspectives.cshlp.org
The control of translation and mRNA degradation is important in the regulation of eukaryotic
gene expression. In general, translation and steps in the major pathway of mRNA decay are …

Eukaryotic stress granules: the ins and outs of translation

JR Buchan, R Parker - Molecular cell, 2009 - cell.com
The stress response in eukaryotic cells often inhibits translation initiation and leads to the
formation of cytoplasmic RNA-protein complexes referred to as stress granules. Stress …

Alternative pre-mRNA splicing regulation in cancer: pathways and programs unhinged

CJ David, JL Manley - Genes & development, 2010 - genesdev.cshlp.org
Alternative splicing of mRNA precursors is a nearly ubiquitous and extremely flexible point of
gene control in humans. It provides cells with the opportunity to create protein isoforms of …

RNA regulons: coordination of post-transcriptional events

JD Keene - Nature Reviews Genetics, 2007 - nature.com
Recent findings demonstrate that multiple mRNAs are co-regulated by one or more
sequence-specific RNA-binding proteins that orchestrate their splicing, export, stability …

P bodies and the control of mRNA translation and degradation

R Parker, U Sheth - Molecular cell, 2007 - cell.com
Recent results indicate that many untranslating mRNAs in somatic eukaryotic cells assemble
into related mRNPs that accumulate in specific cytoplasmic foci referred to as P bodies …

RNA granules: post-transcriptional and epigenetic modulators of gene expression

P Anderson, N Kedersha - Nature reviews Molecular cell biology, 2009 - nature.com
The composition of cytoplasmic messenger ribonucleoproteins (mRNPs) is determined by
their nuclear and cytoplasmic histories and reflects past functions and future fates. The …

Tristetraprolin (TTP): interactions with mRNA and proteins, and current thoughts on mechanisms of action

SA Brooks, PJ Blackshear - Biochimica et Biophysica Acta (BBA)-Gene …, 2013 - Elsevier
Changes in mRNA stability and translation are critical control points in the regulation of gene
expression, particularly genes encoding growth factors, inflammatory mediators, and proto …

[HTML][HTML] Stress granule mediated protein aggregation and underlying gene defects in the FTD-ALS spectrum

Y Baradaran-Heravi, C Van Broeckhoven… - Neurobiology of …, 2020 - Elsevier
Stress granules (SGs) are dynamic membraneless compartments composed out of RNA-
binding proteins (RBPs) and RNA molecules that assemble temporarily to allow the cell to …

AU-rich elements and associated factors: are there unifying principles?

C Barreau, L Paillard, HB Osborne - Nucleic acids research, 2005 - academic.oup.com
The control of mRNA stability is an important process that allows cells to not only limit, but
also rapidly adjust, the expression of regulatory factors whose over expression may be …