NLRP3 inflammasome—a key player in antiviral responses
C Zhao, W Zhao - Frontiers in immunology, 2020 - frontiersin.org
The NACHT, LRR, and PYD domains-containing protein 3 (NLRP3) inflammasome is an
oligomeric complex comprised of the NOD-like receptor NLRP3, the adaptor ASC, and …
oligomeric complex comprised of the NOD-like receptor NLRP3, the adaptor ASC, and …
Inflammasome signalling in brain function and neurodegenerative disease
The mammalian CNS is an intricate and fragile structure, which on one hand is open to
change in order to store information, but on the other hand is vulnerable to damage from …
change in order to store information, but on the other hand is vulnerable to damage from …
SARS-CoV-2 drives NLRP3 inflammasome activation in human microglia through spike protein
Abstract Coronavirus disease-2019 (COVID-19) is primarily a respiratory disease, however,
an increasing number of reports indicate that SARS-CoV-2 infection can also cause severe …
an increasing number of reports indicate that SARS-CoV-2 infection can also cause severe …
Molecular mechanisms and functions of pyroptosis, inflammatory caspases and inflammasomes in infectious diseases
Cell death is a fundamental biological phenomenon that is essential for the survival and
development of an organism. Emerging evidence also indicates that cell death contributes to …
development of an organism. Emerging evidence also indicates that cell death contributes to …
Coronaviruses: innate immunity, inflammasome activation, inflammatory cell death, and cytokines
The innate immune system acts as the first line of defense against pathogens, including
coronaviruses (CoVs). Severe acute respiratory syndrome (SARS)-CoV and Middle East …
coronaviruses (CoVs). Severe acute respiratory syndrome (SARS)-CoV and Middle East …
Fiery cell death: pyroptosis in the central nervous system
Pyroptosis ('fiery death') is an inflammatory type of regulated cell death (RCD), which occurs
downstream of inflammasome activation. Pyroptosis is mediated directly by the recently …
downstream of inflammasome activation. Pyroptosis is mediated directly by the recently …
Interleukin-1β induces mtDNA release to activate innate immune signaling via cGAS-STING
LD Aarreberg, K Esser-Nobis, C Driscoll, A Shuvarikov… - Molecular cell, 2019 - cell.com
Summary Interleukin-1 beta (IL-1β) is a pleiotropic mediator of inflammation and is produced
in response to a wide range of stimuli. During infection, IL-1β production occurs in parallel …
in response to a wide range of stimuli. During infection, IL-1β production occurs in parallel …
Interleukin-1 as innate mediator of T cell immunity
B Van Den Eeckhout, J Tavernier, S Gerlo - Frontiers in immunology, 2021 - frontiersin.org
The three-signal paradigm tries to capture how the innate immune system instructs adaptive
immune responses in three well-defined actions:(1) presentation of antigenic peptides in the …
immune responses in three well-defined actions:(1) presentation of antigenic peptides in the …
Inflammasomes in the CNS
JG Walsh, DA Muruve, C Power - Nature Reviews Neuroscience, 2014 - nature.com
Microglia and macrophages in the CNS contain multimolecular complexes termed
inflammasomes. Inflammasomes function as intracellular sensors for infectious agents as …
inflammasomes. Inflammasomes function as intracellular sensors for infectious agents as …
STING promotes NLRP3 localization in ER and facilitates NLRP3 deubiquitination to activate the inflammasome upon HSV-1 infection
W Wang, D Hu, C Wu, Y Feng, A Li, W Liu… - PLoS …, 2020 - journals.plos.org
One of the fundamental reactions of the innate immune responses to pathogen infection is
the release of pro-inflammatory cytokines, including IL-1β, processed by the NLRP3 …
the release of pro-inflammatory cytokines, including IL-1β, processed by the NLRP3 …