Tuberculosis (TB) is the leading infectious cause of mortality worldwide, due in part to a
limited understanding of its clinical pathogenic spectrum of infection and disease …

Tuberculous meningitis is especially common in young children and people with untreated
HIV infection, and it kills or disables roughly half of everyone affected. Childhood disease …

Strain-specific genomic diversity in the Mycobacterium tuberculosis complex (MTBC) is an
important factor in pathogenesis that may affect virulence, transmissibility, host response …

To improve understanding of the factors influencing tuberculosis transmission and the role of
pathogen variation, we sequenced all available specimens from patients diagnosed over 15 …

Because genetically monomorphic bacterial pathogens harbour little DNA sequence
diversity, most current genotyping techniques used to study the epidemiology of these …

The wide geographic distribution of one clade of Mycobacterium tuberculosis, the Beijing
genotype family, and its genetic homogeneity, suggests that strains belonging to this …

Our understanding of the tuberculosis (TB) epidemic in children is incomplete due to
challenges in diagnosis and reporting. Children have also been largely excluded from …

Renewed efforts in tuberculosis (TB) research have led to important new insights into the
biology and epidemiology of this devastating disease. Yet, in the face of the modern …

Mycobacterium tuberculosis (Mtb) strains are classified into different phylogenetic lineages
(L), three of which (L2/L3/L4) emerged from a common progenitor after the loss of the …

The diverse clinico-and histopathological features, frequency of transmission and treatment
outcome of Mycobacterium tuberculosis have been associated with several environmental …