Since praziquantel was developed in 1970s, it has replaced other antischistosomal drugs to
become the only drug of choice for treatment of human schistosomiases, due to high …

Macrophages regulate the initiation, maintenance, and resolution of chronic inflammatory
responses and their function depends on their activation status. Studies in mice infected with …

Background and Purpose Praziquantel is a schistosomicide, which has been used for more
than 30 years due to its efficiency, safety, and mild side effects. Previous studies showed that …

Background Praziquantel (PZQ) is an isoquinoline derivative (2-cyclohexylcarbonyl-1, 2, 3,
6, 7, 11b-hexahydro-4H-pyrazino {2, 1-a}-isoquinoline-4-one), and is currently the drug of …

Infections caused by parasitic flatworms impose a considerable worldwide health burden.
One of the most impactful is schistosomiasis, a disease caused by parasitic blood flukes …

Schistosomiasis is a major neglected tropical disease. Control of schistosomiasis currently
relies on a single drug, praziquantel, and despite its efficacy against the all schistosome …

S chistosomiasis japonica is a severe tropical disease caused by the parasitic worm S
chistosoma japonicum. Among the most serious pathological effects of S. japonicum …

Schistosomiasis remains to be a significant public health problem in tropical and subtropical
regions. Despite remarkable progress that has been made in the control of the disease over …

Schistosomiasis is a widespread parasitic infection that affects humans, as well as wild and
domestic animals. It ranks second after malaria, with a significant health and socio-economic …

Liver fibrosis can result from various causes and could progress to cirrhosis and cancer;
however, there are no effective treatments due to that its molecular mechanism is unclear …