Rational design in photopharmacology with molecular photoswitches

P Kobauri, FJ Dekker, W Szymanski… - Angewandte Chemie …, 2023 - Wiley Online Library
Photopharmacology is an attractive approach for achieving targeted drug action with the use
of light. In photopharmacology, molecular photoswitches are introduced into the structure of …

Visible light‐driven molecular switches and motors: recent developments and applications

H Wang, HK Bisoyi, X Zhang… - Chemistry–A European …, 2022 - Wiley Online Library
Inspired by human vision, a diverse range of light‐driven molecular switches and motors
have been developed for fundamental understanding and application in material science …

Small-molecule photoswitches for fluorescence bioimaging: engineering and applications

M Olesińska-Mönch, C Deo - Chemical Communications, 2023 - pubs.rsc.org
Fluorescence microscopy has revolutionised our understanding of biological systems,
enabling the visualisation of biomolecular structures and dynamics in complex systems. The …

Hemipiperazines as peptide-derived molecular photoswitches with low-nanomolar cytotoxicity

S Kirchner, AL Leistner, P Gödtel… - Nature …, 2022 - nature.com
Molecular photoswitches transform light energy into reversible structural changes. Their
combination with known pharmacophores often allows for photomodulation of the biological …

Bioactive aurones, indanones, and other hemiindigoid scaffolds: medicinal chemistry and photopharmacology perspectives

LM Lazinski, G Royal, M Robin… - Journal of Medicinal …, 2022 - ACS Publications
Hemiindigoids comprise a range of natural and synthetic scaffolds that share the same
aromatic hydrocarbon backbone as well as promising biological and optical properties. The …

Photoswitchable hemithioindigo inspired copper ion selective sensing with excellent selectivity and versatile operational modes

Q Chen, Y Wang, J Zhai, X Xie - Sensors and Actuators B: Chemical, 2023 - Elsevier
Copper is an essential element in living organisms and the monitoring of copper ions in
aquatic environments and biological systems is of great significance. Inspired by a family of …

Heterocyclic hemithioindigos: highly advantageous properties as molecular photoswitches

V Josef, F Hampel, H Dube - … Chemie International Edition, 2022 - Wiley Online Library
A survey of heterocyclic hemithioindigo photoswitches is presented identifying a number of
structural motives with outstanding property profiles. The highly sought‐after combination of …

A cross-conjugation approach for high-performance diaryl-hemithioindigo photoswitches

M Zitzmann, F Hampel, H Dube - Chemical Science, 2023 - pubs.rsc.org
Diaryl-hemithioindigos (diaryl-HTIs) are derivatives of a novel class of highly functionalized
indigoid chromophores. In this work a systematic study of the electronic effects on their …

In Vivo Photocontrol of Microtubule Dynamics and Integrity, Migration and Mitosis, by the Potent GFP-Imaging-Compatible Photoswitchable Reagents SBTubA4P and …

L Gao, JCM Meiring, A Varady, IE Ruider… - Journal of the …, 2022 - ACS Publications
Photoswitchable reagents are powerful tools for high-precision studies in cell biology. When
these reagents are globally administered yet locally photoactivated in two-dimensional (2D) …

Proton-coupled photochromic hemithioindigo: toward photoactivated chemical sensing and imaging

J Li, X Ma, Y Wang, Y Cheng, Y Qin, J Zhai… - Analytical …, 2023 - ACS Publications
We report photoswitchable fluorescent hemithioindigos (HTIs) where the metastable E
isomers were stabilized by the proton-bridged intramolecular hydrogen bond. Titration …