Photopharmacology is an attractive approach for achieving targeted drug action with the use
of light. In photopharmacology, molecular photoswitches are introduced into the structure of …

Photoswitchable lipids are emerging tools for the precise manipulation and study of lipid
function. They can modulate many aspects of membrane biophysics, including permeability …

Conspectus Membranes are multifunctional supramolecular assemblies that encapsulate
our cells and the organelles within them. Glycerophospholipids are the most abundant …

Serotonin receptors play central roles in neuromodulation and are critical drug targets for
psychiatric disorders. Optical control of serotonin receptor subtypes has the potential to …

Glycerophospholipids are major components of cellular membranes and provide important
signaling molecules. Besides shaping membrane properties, some bind to specific receptors …

Adult central nervous system (CNS) neurons down-regulate growth programs after injury,
leading to persistent regeneration failure. Coordinated lipids metabolism is required to …

Many aspects of cell signaling are controlled by lipids. Several signaling lipids have been
functionalized with an azobenzene photoswitch to control underlying signaling dynamics …

Photodynamic therapy (PDT), which utilizes photosensitizer to convert molecular oxygen
into singlet oxygen (1O2) upon laser irradiation to ablate tumors, will exacerbate the already …

A visible-light-mediated protocol for the hydroacylation of azobenzenes with α-keto acids
has been developed. In the absence of any catalyst or additive, decarboxylative …

The field of photopharmacology of Class A GPCR ligands has recently attracted attention. In
this review we analyze 31 papers on currently available photoswitchable ligands for Class A …