Functions and regulation of the APOBEC family of proteins
HC Smith, RP Bennett, A Kizilyer… - Seminars in cell & …, 2012 - Elsevier
APOBEC1 is a cytidine deaminase that edits messenger RNAs and was the first enzyme in
the APOBEC family to be functionally characterized. Under appropriate conditions …
the APOBEC family to be functionally characterized. Under appropriate conditions …
HIV genome-wide protein associations: a review of 30 years of research
G Li, E De Clercq - Microbiology and Molecular Biology Reviews, 2016 - Am Soc Microbiol
The HIV genome encodes a small number of viral proteins (ie, 16), invariably establishing
cooperative associations among HIV proteins and between HIV and host proteins, to invade …
cooperative associations among HIV proteins and between HIV and host proteins, to invade …
Off-target RNA mutation induced by DNA base editing and its elimination by mutagenesis
Recently developed DNA base editing methods enable the direct generation of desired
point mutations in genomic DNA without generating any double-strand breaks,–, but the …
point mutations in genomic DNA without generating any double-strand breaks,–, but the …
The ClusPro web server for protein–protein docking
Abstract The ClusPro server (https://cluspro. org) is a widely used tool for protein–protein
docking. The server provides a simple home page for basic use, requiring only two files in …
docking. The server provides a simple home page for basic use, requiring only two files in …
The APOBEC3C crystal structure and the interface for HIV-1 Vif binding
S Kitamura, H Ode, M Nakashima, M Imahashi… - Nature structural & …, 2012 - nature.com
The human apolipoprotein B mRNA-editing enzyme catalytic polypeptide–like 3 (APOBEC3,
referred to as A3) proteins are cellular cytidine deaminases that potently restrict retrovirus …
referred to as A3) proteins are cellular cytidine deaminases that potently restrict retrovirus …
Comparison and druggability prediction of protein–ligand binding sites from pharmacophore-annotated cavity shapes
Estimating the pairwise similarity of protein–ligand binding sites is a fast and efficient way of
predicting cross-reactivity and putative side effects of drug candidates. Among the many …
predicting cross-reactivity and putative side effects of drug candidates. Among the many …
Structure‐based approaches to target fishing and ligand profiling
D Rognan - Molecular Informatics, 2010 - Wiley Online Library
Chemogenomics is an emerging interdisciplinary field aiming at identifying all possible
ligands of all possible targets. If one groups targets in columns and ligands in rows …
ligands of all possible targets. If one groups targets in columns and ligands in rows …
Structure-based systems biology for analyzing off-target binding
Here off-target binding implies the binding of a small molecule of therapeutic interest to a
protein target other than the primary target for which it was intended. Increasingly such off …
protein target other than the primary target for which it was intended. Increasingly such off …
Deamination hotspots among APOBEC3 family members are defined by both target site sequence context and ssDNA secondary structure
YZ McDaniel, D Wang, RP Love… - Nucleic acids …, 2020 - academic.oup.com
The human apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3 (APOBEC3,
A3) family member proteins can deaminate cytosines in single-strand (ss) DNA, which …
A3) family member proteins can deaminate cytosines in single-strand (ss) DNA, which …
Human LINE-1 restriction by APOBEC3C is deaminase independent and mediated by an ORF1p interaction that affects LINE reverse transcriptase activity
AV Horn, S Klawitter, U Held, A Berger… - Nucleic acids …, 2014 - academic.oup.com
Abstract LINE-1 (L1) retrotransposons are mobile genetic elements whose extensive
proliferation resulted in the generation of∼ 34% of the human genome. They have been …
proliferation resulted in the generation of∼ 34% of the human genome. They have been …