[HTML][HTML] Angio-LncRs: LncRNAs that regulate angiogenesis and vascular disease

B Yu, S Wang - Theranostics, 2018 - ncbi.nlm.nih.gov
Long noncoding RNAs (lncRNAs) represent a large subgroup of RNAs that are longer than
200 nucleotides and have no apparent protein coding potential. They have diverse functions …

Roles of lncRNAs in brain development and pathogenesis: emerging therapeutic opportunities

T Srinivas, C Mathias, C Oliveira-Mateos, S Guil - Molecular Therapy, 2023 - cell.com
The human genome is pervasively transcribed, producing a majority of short and long
noncoding RNAs (lncRNAs) that can influence cellular programs through a variety of …

Long non-coding RNA MEG3 promotes cerebral ischemia-reperfusion injury through increasing pyroptosis by targeting miR-485/AIM2 axis

J Liang, Q Wang, JQ Li, T Guo, D Yu - Experimental neurology, 2020 - Elsevier
Objective Inflammasome contributes to ischemic brain injury by inducing pyroptosis and
inflammation. The aim of this study is to unravel the mechanism of long non-coding RNA …

LncRNA MALAT1 silencing protects against cerebral ischemia-reperfusion injury through miR-145 to regulate AQP4

H Wang, X Zheng, J Jin, L Zheng, T Guan… - Journal of biomedical …, 2020 - Springer
Background The present study aimed to verify whether long noncoding RNA (lncRNA)
MALAT1 is involved in brain tissue damage induced by ischemia-reperfusion injury, and to …

microRNA-421-3p prevents inflammatory response in cerebral ischemia/reperfusion injury through targeting m6A Reader YTHDF1 to inhibit p65 mRNA translation

L Zheng, X Tang, M Lu, S Sun, S Xie, J Cai… - International …, 2020 - Elsevier
Objective Ischemic stroke is one of the leading causes of death globally, and inflammation is
considered as a vital contributor to the pathophysiology of ischemic stroke. Recently …

Noncoding RNAs in cardiovascular disease: current knowledge, tools and technologies for investigation, and future directions: a scientific statement from the american …

S Das, R Shah, S Dimmeler, JE Freedman… - Circulation: Genomic …, 2020 - Am Heart Assoc
Background: The discovery that much of the non–protein-coding genome is transcribed and
plays a diverse functional role in fundamental cellular processes has led to an explosion in …

LncRNA SNHG14 promotes inflammatory response induced by cerebral ischemia/reperfusion injury through regulating miR-136-5p/ROCK1

Y Zhong, C Yu, W Qin - Cancer gene therapy, 2019 - nature.com
Recently, long non-coding RNAs (lncRNAs) are considered as critical regulators in
pathogenesis progression of cerebral ischemia. In present study, lncRNA-small nucleolar …

Role of regulatory non-coding RNAs in traumatic brain injury

S Li, N Qiu, A Ni, MH Hamblin, KJ Yin - Neurochemistry international, 2024 - Elsevier
Traumatic brain injury (TBI) is a potentially fatal health event that cannot be predicted in
advance. After TBI occurs, it can have enduring consequences within both familial and …

Rho/ROCK pathway and noncoding RNAs: implications in ischemic stroke and spinal cord injury

T Kimura, Y Horikoshi, C Kuriyagawa… - International journal of …, 2021 - mdpi.com
Ischemic strokes (IS) and spinal cord injuries (SCI) are major causes of disability. RhoA is a
small GTPase protein that activates a downstream effector, ROCK. The up-regulation of the …

Long non-coding RNA in CNS injuries: a new target for therapeutic intervention

L Zhang, H Wang - Molecular Therapy-Nucleic Acids, 2019 - cell.com
CNS injuries, such as traumatic brain injury (TBI), subarachnoid hemorrhage (SAH),
intracerebral hemorrhage (ICH), and cerebral ischemic stroke, are important causes of death …