Design, synthesis and molecular docking of new pyrazole-thiazolidinones as potent anti-inflammatory and analgesic agents with TNF-α inhibitory activity

SS Abd El-Karim, HS Mohamed, MF Abdelhameed… - Bioorganic …, 2021 - Elsevier
A new set of derivatives bearing pyrazole-methylenehydrazono-thiazolidinone scaffold 4–23
was designed, synthesized and confirmed by different spectroscopic means and elemental …

Synthesis, computational chemical study, antiproliferative activity screening, and molecular docking of some thiophene-based oxadiazole, triazole, and thiazolidinone …

AS Elgubbi, EAE El-Helw, AYA Alzahrani… - RSC …, 2024 - pubs.rsc.org
Thiophene-2-carbohydrazide was used in this study to produce some thiophene-containing
oxadiazole, triazole, and thiazolidinone derivatives through reactions with various carbon …

The chemo-and regioselectivity of the cyclization of thiosemicarbazides with haloacetic acids and their derivatives

AN Izmest'ev, AА Streltsov, AN Kravchenko… - Chemistry of …, 2022 - Springer
The Chemo- and Regioselectivity of the Cyclization of Thiosemicarbazides with Haloacetic Acids
and their Derivatives | Chemistry of Heterocyclic Compounds Skip to main content SpringerLink …

Design, synthesis and in silico studies of new quinazolinone derivatives as antitumor PARP-1 inhibitors

SK Ramadan, EZ Elrazaz, KAM Abouzid… - RSC …, 2020 - pubs.rsc.org
Herein, we report an eco-friendly synthesis of a new series of quinazolinone-based
derivatives as potential PARP-1 inhibitors. The 4-quinazolinone scaffold was utilized as a …

Straightforward synthesis, antiproliferative screening, and density functional theory study of some pyrazolylpyrimidine derivatives

KNM Halim, SA Rizk, MA El‐Hashash… - Journal of …, 2021 - Wiley Online Library
Tetrahydropyrimidinone derivative was synthesized through one‐pot three components
condensation of 1, 3‐diphenylpyrazole‐4‐carbaldehyde with pentan‐2, 4‐dione and urea …

Synthesis, DFT, and eco-friendly insecticidal activity of some N-heterocycles derived from 4-((2-oxo-1, 2-dihydroquinolin-3-yl) methylene)-2-phenyloxazol-5 (4H)-one

EA Ghareeb, NFH Mahmoud, EA El-Bordany… - Bioorganic …, 2021 - Elsevier
A new series of nitrogen heterocycles encompassing a quinoline scaffold such as
imidazolone, benzimidazole, triazinone, triazole, and thiazole derivatives was synthesized …

Synthesis, antiproliferative activity, and molecular docking of some N‐heterocycles bearing a pyrazole scaffold against liver and breast tumors

SK Ramadan, AK El‐Ziaty, RS Ali - Journal of Heterocyclic …, 2021 - Wiley Online Library
A new series of some 1, 3‐diphenylpyrazole‐based heterocycles were constructed from 2‐
cyano‐3‐(1, 3‐diphenyl‐1 H‐pyrazol‐4‐yl) propenoyl chloride (1). The titled acid chloride …

New potential fungicides pyrazole-based heterocycles derived from 2-cyano-3-(1,3-diphenyl-1H-pyrazol-4-yl) acryloyl isothiocyanate

SK Ramadan, NA Ibrahim, SA El-Kaed… - Journal of Sulfur …, 2021 - Taylor & Francis
New series of pyrazole-based heterocyclic systems were synthesized using 2-
cyanopropenoyl isothiocyanate derivative as an intermediate through treating with some …

Synthesis and antioxidant evaluation of some heterocyclic candidates from 3-(1,3-diphenyl-1H-pyrazol-4-yl)-2-(4-oxo-4H-benzo[d][1,3]oxazin-2-yl)propenonitrile

SK Ramadan, AK El-Ziaty… - Synthetic Communications, 2021 - Taylor & Francis
A new series of quinazoline derivatives bearing a 1, 3-diphenylpyrazole core was
synthesized starting from 3-(1, 3-diphenyl-1 H-pyrazol-4-yl)-2-(4-oxo-4 H-benzo [d][1, 3] …

Synthesis and antimicrobial activity of thiophene-based heterocycles derived from thiophene-2-carbohydrazide

EAE El-Helw, AYA Alzahrani… - Future Medicinal …, 2024 - Taylor & Francis
Aim: Thiophene-based heterocycles were synthesized and evaluated for their antimicrobial
activity against methicillin-resistant Staphylococcus aureus, Escherichia coli, Clostridium …